We describe a novel technique to bleb needling by injecting subconjunctival ologen through an intraocular lens (IOL) delivery system to modulate wound healing in a failing filter. Bleb needling with 26G needle was performed, followed by subconjunctival injection of a biodegradable collagen implant using an IOL delivery system with cartridge in two eyes with a failing filter and high intraocular...

Two patients with history of trabeculectomy presented with uncontrolled intraocular pressure (IOP) postoperatively. The first patient had a flat and vasularized bleb 10 weeks after the surgery, and the second subject developed encapsulated bleb 3 months postoperatively. Both patients were taken to the operating room and intraoperative optical coherence tomography (OCT) guided bleb needling was ...

Bleb formation has been correlated with nonmuscle myosin II (NM-II) activity. Whether three isoforms of NM-II (NM-IIA, -IIB and -IIC) have the same or differential roles in bleb formation is not well understood. Here we report that ectopically expressed, GFP-tagged NM-II isoforms exhibit different types of membrane protrusions, such as multiple blebs, lamellipodia, combinations of both, or abse...

PURPOSE Comparison of the demographic, ocular, systemic and microbiological characteristics of eyes with bleb related infection (BRI) and bleb related endophthalmitis (BRE). METHODS Retrospective chart review of patients with BRI from January 1996-July 2013. Identification done via the center's longstanding endophthalmitis audit, BRI audit and laboratory database identifying all conjunctival ...

The use of antimetabolites in filtration surgery, cystic, large, leaking blebs often lead to complications. We report a case of glaucoma that received amniotic membrane transplantation for repairing the exuberant bleb. This female patient had a history of several eye surgeries, including a scleral buckle and cyclocryotherapy for one eye and the other received filtering surgery. The latter had b...

OBJECTIVE To analyse blebs of phacotrabeculectomies performed with Ologen collagen implants (ProTop & MediKing, Taipei, Taiwan) and to compare these with blebs of mitomycin C (MMC)–augmented phacotrabeculectomies. METHODS 33 participants underwent phacotrabeculectomy with Ologen implants, and 33 controls underwent phacotrabeculectomy with MMC. Blebs were analysed for height and area using ant...

A prospective trial of topical antiprostaglandins versus placebo in the treatment of postoperative fistulising surgery followed up for 12 months is described. It is concluded that antiprostaglandins have little place in the management of these cases. A photographic record of evolution of the fistulising bleb is described, together with a scoring system devised for the evolution of the successfu...

Purpose To raise awareness of a possible association between continuous positive airway pressure (CPAP) devices and postoperative bleb-related infection. Observations A 57-year old patient on CPAP presented with unilateral bleb-associated endophthalmitis 32 months after routine ExPress Trabeculectomy with mitomycin C. The offending organism, Streptococcus mitis, is a nonmotile and generally n...

A cellular bleb grows when a portion of the cell membrane detaches from the underlying cortex under the influence of a cytoplasmic pressure. We develop a quantitative model for the growth and dynamics of these objects in a simple two-dimensional setting. In particular, we first find the minimum cytoplasmic pressure and minimum unsupported membrane length for a stationary bleb to nucleate and gr...