Brief summary: This mouse study identifies FABP4 (‘Fabkin’) as a new fat-derived hormone that regulates insulin-producing beta cells in the pancreas.

Indian traditional system of medicine has been used plants and herbs for treatment of diabetes since time of Vedic glory. In this regard many plants still untouched, having remarkable efficacy. The blood sugar lowering effect of 95% ethanolic extract of C. tamala ( Hamm.) Nees. & Eberm., leaves was investigated at single oral dose of 250mg/kg body weight in normal fasted, fed, glucose loaded...

Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...

Introduction: Skin dose and depth dose distribution of some beta sources that can contaminate skin or protective clothing covering the skin have been calculated using VARSKIN2. Materials and Methods: In this research, absorbed dose to skin and depth dose from the skin surface have been calculated for 90Sr/90Y, 147Pm, 32P beta emitter radioisotopes by using input parameters: activity of source, ...

Background Beta cell dysfunction and death are critical steps in the development of both type 1 2 diabetes (T1D T2D), but underlying mechanisms incompletely understood. Activation essential tumor suppressor transcription factor P53 was linked to beta vitro has been reported several mouse models cells humans with T2D. Therefore, we investigated specific role dysfunction, vivo.

background: luteinizing hormone (lh) was secreted by the stimulating cells of the testes and ovaries in the anterior pituitary gland. the application of this hormone is in the treatment of men and women with infertility and amenorrhea respectively. m aterials and methods: in the present study the alpha and beta subunits of human lh gene were cloned into the pegfp-n1 expression vector and produc...