Neural circuits are typically maintained in a state of dynamic equilibrium by balanced synaptic excitation and inhibition. However, brain regions that are particularly susceptible to epilepsy may have evolved additional specialized mechanisms for inhibiting over-excitation. Here we identify one such possible mechanism in the cerebral cortex and hippocampus of mice. Recently it was reported that...

Karachi is the largest metropolitan area in Pakistan and houses about 14.91 million people (2017 census). It industrial hub financial capital of Pakistan, but unfortunately, it facing worst water crisis its history. bestowed with extensive resources, making use them requires a paradigm shift policy management. situation over period three decades, not due to shortage natural resources mismanagem...

High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of...