The clearance rate of liposomal drugs from the circulation is determined by the rate and extent of both drug release and uptake of liposomes by cells of the mononuclear phagocyte system (MPS). Intravenously injected liposomes initially come into contact with serum proteins. The interaction of liposomes with serum proteins is thought to play a critical role in the liposome clearance. Therefore, ...

Nonlinear hunting speeds of railway vehicles running on a tangent track are analytically obtained using Hopf bifurcation theory in this paper. The railway vehicle model consists of nonlinear primary yaw dampers, nonlinear flange contact stiffness as well as the clearance between the wheel flange and rail tread. Linear and nonlinear critical speeds are obtained using Bogoliubov method. A compreh...

background: hemodialysis is a process of removing waste and excess fluid from blood when kidneys cannot function efficiently. it often involves diverting blood to the filter of the dialysis machin to be cleared of toxic substances. fouling of pores in dialysis membrane caused by adhesion of plasma protein and other toxins will reduce the efficacy of the filtre. objective: in this study, the inf...

Chronic bronchitis is in part characterized by mucus hypersecretion and the inability to clear airways of mucus. Despite years of research in this area, to date there are no pharmacologic therapies available to enhance or promote mucociliary clearance. P2Y(2) receptor agonists are a new class of mucoactive compounds that are currently under development for this purpose. This article will review...

The absolute bioavailability of cefprozil, a new oral cephalosporin, in four beagles was evaluated. In this two-way crossover study, each dog received a 125-mg dose of cefprozil either as an oral aqueous solution or as a 15-min intravenous infusion. A high-performance liquid chromatographic assay with UV detection was employed for the determination of cefprozil concentrations in plasma and urin...

We examined the pharmacokinetic behavior of 200 mg of ciprofloxacin administered intravenously to 32 volunteers whose renal function as measured by creatinine clearance ranged from 0 to 8.99 liters/h per 1.73 m2. Serum clearances (mean +/- standard deviation) were 26.8 +/- 5.7 and 15.4 +/- 4.3 liters/h per 1.73 m2 in normal and anephric volunteers, respectively. The half-life (mean +/- standard...