Death by respiratory complications from influenza infections continues to be a major global health concern. Antiviral drugs are widely available for therapy and prophylaxis, but viral mutations have resulted in resistance that threatens to reduce the long-term utility of approved antivirals. Vaccination is the best method for controlling influenza, but vaccine strategies are blunted by virus an...

This is an application for an adjuvanted, inactivated vaccine against avian influenza. This disease occurs worldwide and not only affects domestic poultry, but also infects a wide range of feral birds covering 88 species and 22 families, occurring most prolifically in migratory waterfowl. Type A influenza virus can also infect various species of mammals (including humans). The main reservoir of...

Recent outbreaks of highly pathogenic avian influenza in Asia and associated human infections have led to a heightened level of awareness and preparation for a possible influenza pandemic. Vaccination is the best option by which spread of a pandemic virus could be prevented and severity of disease reduced. Production of live attenuated and inactivated vaccine seed viruses against avian influenz...

CONTEXT Influenza remains a serious threat and is the most frequent cause of death from a vaccine-preventable disease. Physicians' understanding of influenza and its management and prevention can potentially reduce the spread of disease in the community. OBJECTIVE To ascertain physicians' knowledge of the prevention, identification, and treatment of seasonal and avian influenza. METHODS A 1...

Influenza is an infectious respiratory pathogen causing annual outbreaks and infrequent pandemics, resulting in significant morbidity, mortality and burdens on the delivery of health care. The geographical spread of highly pathogenic avian influenza (HPAI) H5N1 among poultry and wild bird populations is unprecedented. Growing numbers of sporadic avian influenza infections are occurring in human...

Background and Objective: Influenza is a global epidemic disease that always causes irreparable damage to individuals and countrieschr('39') health, and the amount of research in this area is increasing. The primary purpose this study is to discover the hidden patterns and emerging events of global influenza publications. Materials and Methods: This article is an applied type was done with an ...

Recent avian and swine-origin influenza virus outbreaks illustrate the ongoing threat of influenza pandemics. We investigated immunogenicity and protective efficacy of a multi-antigen (MA) universal influenza DNA vaccine consisting of HA, M2, and NP antigens in cynomolgus macaques. Following challenge with a heterologous pandemic H1N1 strain, vaccinated animals exhibited significantly lower vir...

H5N1 highly pathogenic avian influenza (HPAI) was one of the most important avian diseases in poultry production of China, especially in Guangdong province. In recent years, new H5N1 highly pathogenic avian influenza viruses (HPAIV) still emerged constantly, although all poultry in China were immunized with H5N1 vaccinations compulsorily. To better understand the pathogenicity and transmission ...

Highly pathogenic H5N1 avian influenza viruses pose a pandemic threat to human health. A rapid vaccine production against fast outbreak is desired. We report, herein, a paradigm-shift influenza vaccine technology by presenting H5N1 hemagglutinin (HA) to the surface of yeast. We demonstrated, for the first time, that the HA surface-presented yeast can be used as influenza vaccines to elicit both...