نتایج جستجو برای: apoptosis inducing factor

تعداد نتایج: 1012999  

Journal: :Oral oncology 2006
Ferry Sandra Laifa Hendarmin Seiji Nakamura

Osteoprotegerin (OPG) is a useful receptor in inhibiting Receptor Activator of NFkappaB Ligand (RANKL) in inducing osteoclastogenesis. Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a potent apoptosis-inducing ligand in ameloblastomas. Since OPG has been reported to bind to TRAIL as well, the effect of OPG in TRAIL's function in inducing apoptosis should also be invest...

Journal: :Frontiers in bioscience 2014
Yingyi He Benshang Li Hui Zhang Changying Luo Shuhong Shen Jingyan Tang Jing Chen Longjun Gu

Acute Myeloid Leukemia (AML), a cancer of the myeloid line of blood cells, progresses rapidly and is typically fatal within weeks or months if left untreated. Asparaginases are a class of enzymatic anti-leukemia agents that induce apoptosis in leukemia cell lines; however, the role of L-asparaginase in the induction of apoptosis in AML cells has not been investigated. In this study, we investig...

Journal: :Molecular cancer research : MCR 2002
Ying Zhang John M Lehman Lisa M Petti

Mortal human fibroblasts can be partially transformed by the bovine papillomavirus E5 oncoprotein through activation of the platelet-derived growth factor beta receptor. Here, we report that these cells undergo massive apoptosis 2 weeks after confluence. Although activation of caspase 3 was observed in the apoptotic cells, it was not required for apoptosis. The appearance of the mitochondrial p...

Journal: :Blood 2007
Suizhao Wang Shu Wang Hoyoung Maeng Daniel P Young Om Prakash Luis E Fayad Anas Younes Felipe Samaniego

Expression of the K1 gene of human herpesvirus 8 activates nuclear factor-kappaB and induces lymph node hyperplasia and lymphomas in transgenic mice. To further delineate its role in cell survival, we determined whether K1 altered apoptosis of lymphoma cells. K1 protein is expressed in Kaposi sarcoma and primary effusion lymphoma. We retrovirally transfected BJAB lymphoma, THP-1, U937, and Kapo...

Journal: :The international journal of biochemistry & cell biology 2010
Chia-Ying Lin Hung-Yi Wu Pei-Ling Wang Chiun-Jye Yuan

In this study, it was shown that the mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells. The staurosporine-induced apoptosis was reduced by around 65% by the selective knockdown of Mst3 in stable clones, HeLa(siMst3). Although caspases were shown to be involved in the Mst3-mediated apoptosis, only 15-20...

Journal: :Cancer research 2004
Marina Konopleva Twee Tsao Zeev Estrov Ruey-min Lee Rui-Yu Wang C Ellen Jackson Teresa McQueen Giuseppe Monaco Mark Munsell John Belmont Hagop Kantarjian Michael B Sporn Michael Andreeff

In acute myeloid leukemia (AML), resistance to chemotherapy is associated with defects in both the extrinsic and intrinsic pathways of apoptosis. Novel agents that activate endogenous apoptosis-inducing mechanisms directly may be potentially useful to overcome chemoresistance in AML. We examined the mechanisms of apoptosis induction by the novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1...

Journal: :Circulation 2013
Jun Feng Yuhong Liu Nikola Dobrilovic Louis M Chu Cesario Bianchi Arun K Singh Frank W Sellke

BACKGROUND We investigated the effects of cardioplegic arrest and reperfusion (CP/Rep) on myocardial apoptosis and key apoptotic mediators, such as apoptosis-inducing factor, caspase 3, caspase 8, caspase 9, poly(adenosine diphosphate-ribose) polymerase, B-cell lymphoma 2 (Bcl-2) family proteins, and protein kinase C (PKC), in uncontrolled type 2 diabetic, controlled type 2 diabetic, and nondia...

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