Apoptosis is the natural programmed cell death process, which responsible for abnormal clearance. However, many cancer cells develop various mechanisms to escape apoptosis through interrupting apoptosome assembly, a key step initiate apoptosis. This promotes tumorigenesis and drug resistance, thus, poses great challenge in treatment. Herein, biomimetic lipid nanocarrier mimicking mitochondrial ...

Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8-(4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-...

background and objectives: oxidative stress is implicated in the neuronal damage associated with alzheimer’s disease, parkinson’s disease, huntington’s disease, amyotropic lateral sclerosis and cerebral ischemic stroke. the present work was designed to establish the neuroprotective effects of salvia aristata extract on h2o2-induced apoptosis in human dopaminergic sh-sy5y cells. methods: the tot...

Considering multiple reports on cytotoxic activity of the Artemisia genus and its phytochemicals, in the current study A. armeniaca Lam. and the three components isolated from the plant were subjected to cytotoxic studies. Analytical fractionation of A. armeniaca aerial parts for the first time was directed to the isolation of 7-hydroxy-8-(4-hydroxy-3-methylbutoxy) comarin (armenin), 8-hydroxy-...

Background: The qualitative computers (laptop) are as one of the sources of electromagnetic fields (EMF) and these waves are emitted from laptop when you are working with it or connecting to the internet (wireless).The aim of this study is assaying the effects of 2.4GHz waves on the spermatogenesis cycle at the time of connecting to the internet. Materials and Methods: In this study, 36 adult W...

the pathogenesis of equine grass sickness (egs) has not fully understood. a better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. previous studies reported some pathological damage of neuronal cells in egs patients. in this study, primarily cytotoxicity of serum from three clinically egs-diagnosed horses on pc12 tet-off (pto) cells was assessed. subs...

Background and objectives: Achillea is an ancient medicinal herb. The genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. There are also several reports in Iranian Traditional Medicine (ITM) texts about its anti-tumor effect. The cytotoxic activity of the methanol extract of Achil...

The aim of the study is to evaluate ethanol extract Rheum ribes root (RTE), as well and young shoots (RYSE), for its chemical composition, antioxidant properties cytotoxic effects. Total polyphenols (TPC), total flavonoid (TFC), radical scavenging activity (DPPH), ferric reducing power (FRAP) extracts were determined using colorimetric methods. Mineral contents vitamin values samples by ICP-MS ...

Objective: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-rene...