conclusions the results of antifungal susceptibility tests demonstrated that voriconazole was the most active drug against candida isolates. candida albicans is the most common yeast isolated from human blood world-wide; the unexpectedly higher rate of c. parapsilosis isolated in this study necessitates more studies with larger sample sizes in iran. results candida parapsilosis (c. parapsilosis...

Purpose: To evaluate the efficacy of different modalities of antifungal agents in the treatment, clinical features and therapeutic outcome of fungal keratitis Design: Retrospective observational case series. Methods: The study reviewed 251 eyes of 246 patients treated for moderate and severe fungal keratitis in the period from 2010 to 2015. The diagnosis of fungal keratitis based on the clinica...

background and objectives : the incidence of fungal infections in immunocompromised patients, especially by candida species, has increased in recent years. this study was designed to identify candida species and determine antifungal susceptibility patterns of 595 yeast strains isolated from various clinical specimens. material and methods : identification of the isolates were determined by the ...

Candida species are the leading causes of invasive fungal infection among hospitalized patients and are responsible for major economic burdens. The goals of this study were to estimate the costs directly associated with the treatment of candidemia and factors associated with increased costs, as well as the impact of first-line antifungal agents on the outcomes and costs. A retrospective study w...

INTRODUCTION Because invasive fungal infections cause significant morbidity and mortality in liver transplant recipients, the use of antifungal prophylaxis, and the early empirical use of antifungal agents, is widespread on liver transplant units. The new-generation azoles such as voriconazole and the echinocandins have been welcome additions to the antifungal armamentarium. These agents have b...

Candida dubliniensis is a newly recognized fungal pathogen causing mucosal disease in AIDS patients. Although preliminary studies indicate that most strains of C. dubliniensis are susceptible to established antifungal agents, fluconazole-resistant strains have been detected. Furthermore, fluconazole-resistant strains are easily derived in vitro, and these strains exhibit increased expression of...

This review provides insight into the rapidly expanding field of metal-based antifungal agents.

Background and Purpose: Candida albicans is the most common Candida species (spp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed t...