نتایج جستجو برای: anticonvulsant antitubercular

تعداد نتایج: 6799  

2014
Poonam Kohli S. K. Srivastava S. D. Srivastava

As a part of our research to develop novel antimicrobial and antitubercular agents, a series of 4-(2-aryl-4-oxo-1,3thiazolidine)-5-mercapto-3-(5-nitroindazolyl methyl)-1,2,4triazoles (5a-j) have been synthesized by conventional as well as microwave method. The structures of these compounds were confirmed by IR, H NMR, C NMR, FABmass spectra and also by microanalytical data. These compounds were...

Journal: :Indian pediatrics 2008
Rakesh Lodha P Ramesh Menon S K Kabra

The Revised National Tuberculosis Control Program (RNTCP) has initiated provision of antitubercular therapy for children with strategy of patient-wise boxes for the 4 different weight bands (6- 10 kg; 11- 17 kg; 18- 25 kg; 26- 30 kg). We evaluated the dose of individual drugs delivered by this approach to children of varying weights. The following areas of concern were identified: underdosing o...

Journal: :The Journal of bone and joint surgery. British volume 2007
S A Khan M K Varshney A S Hasan A Kumar V Trikha

A series of 14 patients suffering from tuberculosis of the sternum with a mean follow-up of 2.8 years (2 to 3.6) is presented. All were treated with antitubercular therapy: ten with primary therapy, two needed second-line therapy, and two required surgery (debridement). All showed complete healing and no evidence of recurrence at the last follow-up. MRI was useful in making the diagnosis at an ...

Journal: :Neurology 1984
S E Thurston R J Leigh L A Abel L F Dell'Osso

We report a patient with abnormal saccades in association with anticonvulsant toxicity (phenytoin 27.5 micrograms/ml, phenobarbital 18.8 micrograms/ml). The patient looked toward visual targets either with multiple, small, hypometric saccades or with single slow saccades. These abnormalities resolved when anticonvulsant levels returned to therapeutic range. Thus, slow saccades may be clinical e...

Journal: :Bioorganic & medicinal chemistry 2007
Anita Mahapatra Sannah P N Mativandlela B Binneman P B Fourie Chris J Hamilton J J M Meyer F van der Kooy Peter Houghton Namrita Lall

The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the 7-methyljuglone scaffold have been prepared and evaluated for antibacterial activity against Myco...

2009
Gautam Panda Maloy Kumar Parai Ajay Kumar Srivastava Vinita Chaturvedi Y K Manju Sudhir Sinha

Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on ary...

2015
Dinesh R Godhani Anand A Jogel Anil M Sanghani Jignasu P Mehta

A series of 2-((arylamino)methyl)-5-(3-methoxyphenyl)-1-phenyl-1H-1,2,4-triazole-3-thione derivatives have been synthesized and characterized by FT-IR, NMR, mass spectral and elemental analysis. Compounds (MM4a-m) have been evaluated for their in vitro antibacterial activity against selected gram-positive and gram-negative bacteria and in vitro antifungal activity against fungal pathogens by us...

Journal: :Indian journal of physiology and pharmacology 1992
N Siddigui S N Pandeya

In our previous studies we have reported the CNS activities of the synthesised heterocyclic ring compounds (1,2). Certain phenylurethanes of pyrazolidinols and piperidazinols have moderate anticonvulsant activity (3). Some 2-(N-substituted glycylamino)-methylthiazoles and (l-phenyl-l-hydroxycthyl) azoles have been found to possess, anticonvulsant and anxiolytic activities (4,5). A series of 5-a...

Journal: :Journal of clinical pharmacy and therapeutics 2015
R G dos Santos J E C Hallak J P Leite A W Zuardi J A S Crippa

WHAT IS KNOWN AND OBJECTIVE Antiepileptic drugs often produce serious adverse effects, and many patients do not respond to them properly. Phytocannabinoids produce anticonvulsant effects in preclinical and preliminary human studies, and appear to produce fewer adverse effects than available antiepileptic drugs. The present review summarizes studies on the anticonvulsant properties of phytocanna...

2012
Nan Jiang Xian-Qing Deng Fu-Nan Li Zhe-Shan Quan

Considerable interest has been focused on the triazole structure, which has been known to possess a broad spectrum of biological activities such as antitumor, anti-inflammatory, antimicrobial, antiviral, and anticonvulsant activities. Before this, several heterocyclic compounds containing triazole were synthesized that had shown considerable anticonvulsant activity. As part of our continuous re...

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