نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

Journal: :Journal of virology 2008
Takahiro Masaki Ryosuke Suzuki Kyoko Murakami Hideki Aizaki Koji Ishii Asako Murayama Tomoko Date Yoshiharu Matsuura Tatsuo Miyamura Takaji Wakita Tetsuro Suzuki

Nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) possesses multiple and diverse functions in RNA replication, interferon resistance, and viral pathogenesis. Recent studies suggest that NS5A is involved in the assembly and maturation of infectious viral particles; however, precisely how NS5A participates in virus production has not been fully elucidated. In the present study, we de...

2010
Fiona Fernandes Israr-ul H. Ansari Rob Striker

BACKGROUND Hepatitis C Virus (HCV) infection is a leading indication for liver transplantation. HCV infection reoccurs almost universally post transplant, decreasing both graft longevity and patient survival. The immunosuppressant, cyclosporine A (CsA) has potent anti-HCV activity towards both HCV replicons and the genotype 2a cell culture infectious virus. Previously, we isolated mutations in ...

Journal: :Journal of virology 2007
Ella H Sklan Kirk Staschke Tina M Oakes Menashe Elazar Mark Winters Benjamin Aroeti Tsafi Danieli Jeffrey S Glenn

Hepatitis C virus (HCV) is an important cause of liver disease worldwide. Current therapies are inadequate for most patients. Using a two-hybrid screen, we isolated a novel cellular binding partner interacting with the N terminus of HCV nonstructural protein NS5A. This partner contains a TBC Rab-GAP (GTPase-activating protein) homology domain found in all known Rab-activating proteins. As the f...

2013
Du Cheng Lei Zhao Leiliang Zhang Yongfang Jiang Yi Tian Xinqiang Xiao Guozhong Gong

Growth arrest and DNA-damage-inducible gene 45-α (GADD45α) protein has been shown to be a tumour suppressor and is implicated in cell-cycle arrest and suppression of cell growth. The hepatitis C virus (HCV) non-structural 5A (NS5A) protein plays an important role in cell survival and is linked to the development of hepatocellular carcinoma (HCC). However, the role of HCV NS5A in the development...

2012
Troels K. H. Scheel Jannick Prentoe Thomas H. R. Carlsen Lotte S. Mikkelsen Judith M. Gottwein Jens Bukh

Hepatitis C virus (HCV) is an important cause of chronic liver disease. Several highly diverse HCV genotypes exist with potential key functional differences. The HCV NS5A protein was associated with response to interferon (IFN)-α based therapy, and is a primary target of currently developed directly-acting antiviral compounds. NS5A is important for replication and virus production, but has not ...

Journal: :Journal of virology 2002
Yupeng He Haruhisa Nakao Seng-Lai Tan Stephen J Polyak Petra Neddermann Sangeetha Vijaysri Bertram L Jacobs Michael G Katze

Hepatitis C virus (HCV) sets up a persistent infection in patients that likely involves a complex virus-host interaction. We previously found that the HCV nonstructural 5A (NS5A) protein interacts with growth factor receptor-binding protein 2 (Grb2) adaptor protein and inhibits the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) by epidermal growth factor (EGF). In the pre...

Journal: :The Journal of general virology 2004
Takashi Taguchi Motoko Nagano-Fujii Masato Akutsu Hiroyasu Kadoya Shinji Ohgimoto Satoshi Ishido Hak Hotta

The non-structural protein 5A (NS5A) of hepatitis C virus (HCV) has been implicated in inhibition of antiviral activity of IFN. While previous studies have suggested an interaction between NS5A and the double-stranded RNA-dependent protein kinase (PKR), the possibility still remains that interaction with another molecule(s) is involved in the NS5A-mediated inhibition of IFN. In the present stud...

Journal: :Journal of virology 2004
M Kalamvoki P Mavromara

The nonstructural 5A (NS5A) protein of the hepatitis C virus (HCV) is a multifunctional phosphoprotein that is implicated in viral replication and HCV-mediated pathogenesis. We report here that the NS5A protein from the HCV genotype 1a is processed into shorter distinct forms when expressed in mammalian cells (Vero, HepG2, HuH-7, and WRL68) infected with an NS5A-expressing HSV-1-based amplicon ...

Journal: :Journal of immunology 2013
Fredrik Holmström Anna Pasetto Veronica Nähr Anette Brass Malte Kriegs Eberhard Hildt Kate E Broderick Margaret Chen Gustaf Ahlén Lars Frelin

The hepatitis C virus (HCV) nonstructural (NS) 5A protein has been shown to promote viral persistence by interfering with both innate and adaptive immunity. At the same time, the HCV NS5A protein has been suggested as a target for antiviral therapy. In this study, we performed a detailed characterization of HCV NS5A immunogenicity in wild-type (wt) and immune tolerant HCV NS5A-transgenic (Tg) C...

Journal: :Pathogens 2023

Ribonucleotide reductases (RRs or RNRs) catalyze the reduction of OH group on 2nd carbon ribose, reducing four ribonucleotides (NTPs) to corresponding deoxyribonucleotides (dNTPs) promote DNA synthesis. Large viruses, such as herpesviruses and poxviruses, could benefit their replication through increasing dNTPs via expression viral RRs. Little is known regarding relationship between cellular RR...

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