The literature on alcaptonuria has been well summarized (1--6). Paschkis et al. (7) reported that thiouracil and para-aminobenzoic acid inhibited the in vitro conversion of tyrosine to melanin by tryrosinase, and White (8) found that thiouracil inhibited melanuria. Lerner and associates (9) noted that the tyrosinase of mouse melanoma is a copper protein whose activity can be inhibited by the ad...

We investigated effects of poly(ADP-ribose) synthetase (PARS) inhibitors on acoustic trauma. Albino guinea pigs were intravenously given 3-aminobenzamide, nicotinamide or 3-aminobenzoic acid (an inactive analog of 3-aminobenzamide) just prior to exposure to a 2 kHz pure tone of 120 dB sound pressure level (SPL) for 10 minutes. The threshold of the compound action potential (CAP) and the amplitu...

In the present study, ketoprofen-p-aminobenzoic acid (KP-PABA) co-crystal was prepared, to advance solubility and dissolution rate of drug, by solvent evaporation technique employing central composite experimental design. The optimized batch as recommended design characterized FTIR, DSC, XRD, SEM, NMR studies further, evaluated for in-vitro in-vivo anti-inflammatory analgesic activities. % drug...

705 706 708 Reversal of p-Aminobenzoic Acid Inhibition of Growth of Rickettsiae by p-Hydroxybenzoic Acid in Agar-Slant Tissue Culture: N. Takemori and M. Kitaoka . 710 On the Presence of the Triphosphothiamine (TPT) in the Liver: A. Rossi-Fanelli, N. Siliprandi, and P. Fasella . _.711 Comments and Communications Ernest G. Beinhart, H. A. Cole, and Ben Stern .............. 713 Operations Diagnos...

We present three new hybrid copper(II) chloride layered perovskites of generic composition ACuCl4 or A2CuCl4, which exhibit distinct structure types. (m-PdH2)CuCl4 (m-PdH22+ = protonated m-phenylenediamine) adopts a Dion-Jacobson (DJ)-like perovskite type and exhibits very large axial thermal contraction effect upon heating, as revealed via variable-temperature synchrotron X-ray powder diffract...

The test for exocrine pancreatic function using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTPABA test) was assessed in 7 patients with giardiasis and 7 healthy controls. Cumulative percent p-aminobenzoic acid (PABA) recovery in 6 hr was significantly lower in patients with giardiasis, compared with the control group. When an equivalent dose of free PABA was given, there were no differences in PA...

The test for pancreatic exocrine function using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BTP test) does not require duodenal intubation, but misleadingly abnormal results often occur in patients with liver or bowel disease because the p-aminobenzoic acid (PABA) released by chymotrypsin hydrolysis of the peptide either is not conjugated or is malabsorbed. This study evaluated a modified BTP test...