Extremely low frequency electromagnetic fields aren’t considered as a real carcinogenic agent despite the fact that some studies have showed impairment of the DNA integrity in different cells lines. The aim of this study was evaluation of the late effects of a 100 Hz and 5.6 mT electromagnetic field, applied continuously or discontinuously, on the DNA integrity of Vero cells assessed by alkalin...

BACKGROUND Extremely low frequency electromagnetic fields aren't considered as a real carcinogenic agent despite the fact that some studies have showed impairment of the DNA integrity in different cells lines. The aim of this study was evaluation of the late effects of a 100 Hz and 5.6 mT electromagnetic field, applied continuously or discontinuously, on the DNA integrity of Vero cells assessed...

Although, arsenic trioxide has been the subject of toxicological research, in vitro cytotoxicity and genotoxicity studies using relevant cell models and uniform methodology are not well elucidated. Hence, the aim of the present study was to evaluate the cytotoxicity and genotoxicity induced by arsenic trioxide in human keratinocytes (HaCaT) using the MTT [3-(4, 5-dimethylthiazol-2-yl)2,5-diphen...

Abstract: Perfluorooctanoic acid (PFOA) is an emerging environmental contaminant that has been used to make products including microwave popcorn bags and nonstick pans. However, published studies have indicated that long-term of human exposure to this compound increases the risk of prostate cancer. Although clinical manifestations associated with PFOA exposure are well documented, its molecular...

The formation of single-strand breaks and alkali-labile sites on DNA has been extensively used for genotoxicity testing, given its involvement in degenerative disorders, cancer and oxidative stress. An alkaline variation of the single-cell electrophoresis (comet) assay used for the detection of DNA damage was developed during the eighties, providing data on this phenomenon at the level of indiv...

Citation: Langie SAS, Azqueta A and Collins AR (2015) The comet assay: past, present, and future. The alkaline comet assay (single cell gel electrophoresis) is the most widely used method for measuring DNA damage in eukaryotic cells (Neri et al., 2015). It detects strand breaks (SBs) and alkali-labile sites at frequencies from a few hundred to several thousand breaks per cell—a biologically use...

background apoptosis or programmed cell death is an essential process for elimination of damaged cells. also, induction of apoptosis is fundamental for treating cancer. screening for agents that induce apoptosis in tumor cells help in the development of novel agents for cancer treatment. numerous studies suggest that the exposure of tumor cells to statins can lead to cell death via two separate...