A substantial proportion of hitherto unexplained respiratory tract illnesses is associated with human metapneumovirus (hMPV) infection. This virus also was found in patients with severe acute respiratory syndrome (SARS). To determine the dynamics and associated lesions of hMPV infection, six cynomolgus macaques (Macaca fascicularis) were inoculated with hMPV and examined by pathological and vir...

We introduced a patient with fetal EBV-triggered who finally developed multidrug-resistant septicemia, perianal abscess, massive alimentary tract bleeding due to gastrointestinal vascular malformation, and acute respiratory distress syndrome. His EB virus maintained chronically active under multiple drug treatments. Interestingly, continuous infection probable idiopathic malformation might be t...

human coronaviruses–229E and -OC43 and severe acute respiratory syndrome–CoV were able to survive in suspension at room temperature for several days (8,9). Moreover, severe acute respiratory syndrome–CoV was completely inactivated after heat treatment at 60°C for 30 min (9). Human-to-human transmission of MERS-CoV is inefficient, and the transmission route has not yet been revealed. The predomi...

OBJECTIVES To determine the spectrum of N and G genotypes of respiratory syncytial virus (RSV) causing respiratory tract infection and whether particular genotypes are associated with severity of infection. PATIENTS AND METHODS Nasopharyngeal aspirates (NPAs) were obtained from 114 infants with acute respiratory tract infection due to RSV over two seasons. Viral mRNA was extracted from NPAs o...

Measurements of respiratory rate in 82 long-stay patients aged 67-101 years yielded a normal range of 16-25 breaths a minute. In a prospective study of 60 consecutive acute admissions to a geriatric unit, 19 out of 21 patients diagnosed as lower respiratory tract infections had respiratory rates above the upper limit of normal on the day of diagnosis; the rise in respiratory rate preceded the c...

BACKGROUND Acute infection increases the risk of arterial cardiovascular events, but effects on venous thromboembolic disease are less well established. Our aim was to investigate whether acute infections transiently increase the risk of venous thromboembolism. METHODS We used the self-controlled case-series method to study the risk of first deep vein thrombosis (DVT) (n=7278) and first pulmo...

Human bocavirus (HBoV) was first described in 2005 in nasopharyngeal aspirates of children with respiratory tract infection. Multiple studies have confirmed the presence of HBoV in respiratory tract samples of children world-wide. HBoV has recently also been detected in blood and fecal samples. Most studies so far have studied virus prevalence, and only a few reports provide data regarding the ...

BACKGROUND The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS 2.3% of the 3911 children examined had HPeV infection, with most...

drug for the prevention of bronchial asthma and allergic rhinitis attacks. DSCG inhibits the release of chemical mediators, including histamine and tumor necrosis factor, from mast cells. While DSCG is known to induce intracellular signaling events associated with physiological and pathological processes, the molecular mechanisms of DSCGinduced signaling have remained unclear. Recent evidence, ...

Acute Respiratory Tract Infection (ARTI) is a respiratory tract disease that can lead to various illnesses, ranging from asymptomatic conditions fatal ones. In Indonesia, the mortality rate caused by pneumonia ranks second with total of 217 cases. Generally, risk factors for ARTI occurrence include individual factors, environmental and behavioral factors. The aim this study identify contribute ...