A research project was carried out at Institute of Radiotherapy and Nuclear Medicine (IRNUM) Peshawar, in order to investigate the prevalence of different types of leukemias in North West Frontier Province of Pakistan, during 2001. During this study 60 leukemia patients admitted at IRNUM were investigated. It was found that acute leukemia was more prevalent than chronic leukemia as 90% of total...

Terminal deoxynucleotidyl transferase (TdT) was determined by immunofluorescence in 30 patients with leukemia. In acute lymphocytic leukemia the proportion of cells positive for TdT was 19 to 77 percent during relapse (12 cases) and less than one percent during remission (three cases). In seven cases of myeloproliferative disease and two cases of lymphoma, the TdT was less than one percent. In ...

At least 22 members of a large kindred have a bleeding tendency resulting from an autosomal dominant disorder of platelet production and function. Phenotypic manifestations include mild to moderate thrombocytopenia, bleeding time prolongation, and abnormal platelet aggregation. Platelet survival time is normal. The platelet disorder in this family appears to differ from known hereditary thrombo...

The sister chromatid exchange (SCE) frequency was studied in the leukemic cells of 12 patients, 10 with Philadelphia chromosome (Ph1)-positive chronic myelocytic leukemia (CML), 1 with Ph1-negative CML, and 1 with acute myeloblastic leukemia. Except for two patients in the blastic phase of CML, the SCE values were within the normal range [3.8 +/- 6.4 (S.D.) SCE/cell; normal is 3.3 +/- 2.2 SCE/c...

Morphological pattern of 234 consecutive cases of various types of leukemias is presented. Acute leukemias (62.8%) were commoner than chronic (37.2%). Amongst acute leukemias, myeloid leukemias (AML) were more frequent as compared to lymphoblastic (ALL). AML:ALL ratio was 2.57:1 in adults and 1:3 in children. Amongst AML cases, M4 was the commonest, followed by M2, M1, M3 and M4 and M6 and M7 r...

Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identi...

In this issue of Blood, Martelli et al and El Hajj et al independently report that nucleophosmin-1 (NPM1)-mutant leukemia is particularly vulnerable to a novel strategy combining all-trans retinoic acid (ATRA) with arsenic trioxide (ATO). The era of targeted therapy has seen some of its greatest successes in the hematologic arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inhibit...

A 1 2-yr-old boy with acute leukemia was globulin were found in the patient’s serum found to have paraproteinemia and Benceand urine. Electron microscopic and imJones proteinuria. The paraprotein was munofluorescence studies provided cvicharacterized as immunoglobulin M, type i dence of the presence of lymphoid leukemia and the Bence Jones protein as free cells apparently responsible for the pr...

By M. C. BLANCHAER, P. T. GREEN, J. P. MACLEAN AND M. J. HOLLENBERG W IDE ACCEPTANCE of serum glutamic oxaloacetic transaminase estimations1 for the detection of myocardial infarction has stimulated interest in the possible diagnostic uses of other plasma enzymes, including lactic acid dehydrogenase ( LD ) and phosphohexose isomerase ( PHI ) . Both of these enzymes play a role in the intracellu...

By JACQUELINE WHANG-PENG, GEORGE P. CANELLOS, PAUL P. CARBONE AND J. H. Tjio T HE Ph’ CHROMOSOME, with the exception of a few cases of acute leukemia,’5 occurs only in patients with chronic myelocytic leukemia and is still the only consistent chromosome abnormality found in neoplastic diseases.4’9 In about 85 per cent of patients with CML, the Ph1 chromosome is found in most if not all marrow c...