Sulfonamides display a wide variety of pharmacological activities. Sulfamethazine [abbreviated as SMZ; systematic name 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide], one of the constitutents of the triple sulfa drugs, has wide clinical use. Pharmaceutical solvates are crystalline solids of active pharmaceutical ingredients (APIs) incorporating one or more solvent molecules in the cr...

Past studies showed that chemicals in cigarette smoke inhibit oviductal functioning in vivo and in vitro. The purposes of this study were to identify individual toxicants in cigarette smoke solutions that inhibit various aspects of oviductal functioning and to determine their effective doses using in vitro bioassays. Solid phase extraction and gas chromatography-mass spectrometry (GC-MS) were u...

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and ...

The two achiral ligands tris(1-methyl-1H-imidazol-2-yl)methanol ((mim)3COH) and bis(1-methyl-1H-imidazol-2-yl)(3-methylpyridin-2-yl)methanol ((mim)2(mpy)COH) form on reaction with Fe(BF4)2∙6H2O, the octahedral low-spin complexes [Fe((mim)3COH)2](BF4)2∙MeCN (1) [Fe((mim)2(mpy)COH)2](BF4)2∙0.5MeCN (2). Both immediately rearrange to chiral [Fe4O4]-cubane clusters [Fe4(mim)3CO)4](BF4)4 (3) [Fe4(mim...

the synthesis, spectroscopic and magnetic characterization of a series of new alkoxo-bridged binuclear copper (ii) compounds are described. all complexes have the general formula [cu (m-or)(l)2]2(clo4)2 · x h2o, in which m-or = ch3o-, c2h5o- or c3h7o-, l = 2-amino-4-methylpyridine (abbreviated a4pic) and 2-amino-5-methylpyridine ( abbreviated a5pic). the title compounds all consist of dinuclear...

Complex cis-[PtI2(NH3)(pic)] (pic = 2-methylpyridine), an iodido analogue of picoplatin, released the N-donor pic ligand in solution and isomerized, which complicates its subsequent testing for cytotoxicity.