A critical issue for the general application of triple-helix-forming oligonucleotides (TFOs) as modulators of gene expression is the dramatically reduced binding of short TFOs to targets that contain one or two pyrimidines within an otherwise homopurine sequence. Such targets are often found in gene regulatory regions, which represent desirable sites for triple helix formation. Using intercalat...

biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of biginelli pyrimidines. in this study synthesis of some novel biginelli-type pyrimidines is reported. the prepa...

Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 the six membered ring show wide range biological activities. Numerous methods for synthesis pyrimidine their diverse reactions offer enormous scope in field medicinal chemistry. Pyrimidine possesses spectrum activities including antitubercular, antibacterial, antifungal, antiviral, anti-in...

In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuranchalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structuresof title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analyticaland spectral data. The synthesized compounds were screened for antimicrobial activityand molecular docking studies. Some ...

ABSTRACT A simple and efficient approach has been developed to synthesise novel functionalised 5H-chromeno[2,3-d] pyrimidines derivatives (4a-h). This entails treating 2-amino-3-cyano-4H-chromenes (3a-h) with formamidine acetate under microwave irradiations solvent-free conditions. All structures of new compounds obtained in this study were characterised by IR, MS, 1H 13C NMR analysis. Addition...

Some novel annulated pyrido[2,3-d]pyrimidines 6 and 7 were synthesized stereoselectively by intramolecular hetero Diels-Alder reactions involving 1-oxa-1,3-butadienes.

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and m...