It has previously been reported that the cholecystokinin analog JMV-180 behaves differently on the rat and the mouse cholecystokinin-A receptor (CCK-AR). In mice this analog acts as an agonist on low- and high-affinity sites of the CCK-AR, whereas in rats this compound acts as an agonist on high-affinity sites and as an antagonist on low-affinity sites. In an attempt to understand why the same ...

For nearly 4 years a search has been conducted in our laboratories among materials of natural origin for agents having the ability to retard the growth of tumors. Early in the course of this in vestigation crude culture filtrates of the fungus Aspergillus fumigatus were found to retard the growth of the Crocker mouse sarcoma 180 and of the mammary adenocarcinoma E 0771 in mice (4). Meanwhile, K...

We investigated the enhancing effect of two metal-chelating compounds, 2,3-dimercapto-1-propanesulfonic acid (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA), on the antitumor activity of cisplatin (CDDP). In the in vivo experiments, DMPS showed a clear synergistic effect and significantly enhanced the antitumor activity of CDDP in terms of survival and life span in mice transplanted with asc...

The lethal and sublethal effects of hydroxyurea were studied in Sarcoma 180 in vitro in relation to drug concentration and drug exposure duration using cloning methods, radioautography, and flow microfluorometry. It was shown that postperturbation changes in radioautographic labeling intensity reflected real changes in the rate of DNA synthesis in individual cells. The data suggest that both th...

cystic fibrosis (cf) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. more than 90% of mortality of  cf patients is due to lung complications.  healthy lungs are important for a long life for people with cf, we will discuss two important topics for maintaining respiratory health. chronic use of drug...

Objective(s): Inhaled aerocontaminants are removed from the lungs by pulmonary mucociliary transport (MCT) as an important defense mechanism. This study was undertaken to investigate the influence of the surface potential of magnetic nanoparticles (MNPs) on the MCT in murine lungs by use of magnetic particle imaging (MPI).Materials and Methods: Three kinds of MNPs (carboxymethyl dextran m...

Abstract. We present a novel method for detecting rotated lungs in chest radiographs for quality control and augmenting automated abnormality detection. The method computes a principal rib-orientation measure using a generalized line histogram technique for quality control, and therefore augmenting automated abnormality detection. To compute the line histogram, we use line seed filters as kerne...

STUDY OBJECTIVES To examine whether relative hypoperfusion to the apical one third of the lungs as determined by lung scintigraphy predicts a favorable functional outcome following bilateral lung volume reduction surgery (LVRS). METHODS We performed a retrospective analysis of 128 patients who underwent bilateral LVRS. An apical perfusion fraction (AP%), defined as the percentage of total lun...