Vitamin D3 (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin (6a) and 4β,25-dihydroxyvitamin (6b) are both produced from 25-hydroxyvitamin (2) CYP3A4. However, 6b detectable serum, whereas 6a not. We hypothesized that reason for this a difference susceptibility to CYP24A1-mediated metabolism. Here, ...

Studies of extracellular and intracellular n-Lu-hydroxy acids produced by Lactobadlus casei 7469 were prompted by the earlier discovery that certain nutritional mutants derived from this organism, notably L. casei 280-16 and 280-16A (l-3), give a growth response to any one of a wide variety of n-ac-hydroxy acids. n-Lactic acid is the simplest growth-promoting acid for these organisms, although ...

We report a combined experimental (H (Rydberg) atom photofragment translational spectroscopy) and theoretical (ab initio electronic structure and vibronic coupling calculations) study of the effects of symmetry on the photodissociation dynamics of phenols. Ultraviolet photoexcitation to the bound S1((1)ππ*) state of many phenols leads to some O-H bond fission by tunneling through the barrier un...

Phytochemical studies on the ethanolic extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of two new triterpenoidal alkaloids, (+)-16a, 31-diacetylbuxadine (1), (-)-Nb-demethylcyclomikuranine (2) along with three known natural products, (-)-cyclomikuranine (3), (-)-cyclobuxophylline-K (4) and (+)-buxaquamarine (5) isolated for the first time from this sp...

Reactions of N,N;-disubstituted hydrazinecarbothioamides 8a-c and substituted thioureidoethylthioureas 9a-c with 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil, 10a) and 2,3,5,6-tetrabromo-1,4-benzoquinone (bromanil, 10b) to form N,N;-disubstituted [1,3,4]thiadiazole-2,5-diamines 11a-c, 6,7-dichloro-3-substituted amino-1H-benzo[1,3,4]- thiadiazine-5,8-diones 12a-c, 2,3,7,8-tetrahalothianthrene...

A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl(α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a-c, 14-16a,b was synthesized in 78-87% yields via the reaction of methyl 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a-c, 13a-e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory...

The computation of Kemeny rankings is central to many applications in the context of rank aggregation. Unfortunately, the problem is NP-hard. Extending our previous work [AAIM 2008], we show that the Kemeny score of an election can be computed efficiently whenever the average pairwise distance between two input votes is not too large. In other words, Kemeny Score is fixed-parameter tractable wi...