Most patients with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. To better understand the mechanisms that determine the long-term responses of mutant B-Raf melanoma cells to B-Raf inhibitor, we used chronic selection to establish B-Raf (V600E) melanoma clones with acquired resistance to the new oncogenic B-Raf inhibitor UI-152. Whereas the pa...

Other Potential Covariates ........................................................................................... 151 Family ................................................................................................................................151 Religious Community .........................................................................................................151 Local ...

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We have used a monoclonal antibody ESA 152 in fluorescence recovery after photobleaching (FPR) studies of a maturation-dependent surface antigen of ram sperm. The antibody is an immunoglobulin G secreted by a hybridoma derived from NS1 mouse myeloma cells. The ESA 152 antigen is not detectable in testicular sperm. It is localized on the surface of ejaculated sperm where it is present on all reg...

These include: References http://bmj.com/cgi/content/full/328/7432/152#otherarticles 3 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/328/7432/152#BIBL This article cites 2 articles, 1 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/328/7432/152 You can respond to this article at: http://bmj.com/cgi/content/full/328...

PURPOSE The (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), plays an important role in the physiologic and pathophysiological regulation of blood pressure and fluid/electrolyte homeostasis. The RAS including the PRR has been identified in retinal endothelial cells and other ocular tissues. In this study, the potential involvement of miRNAs in the posttranscriptiona...