نتایج جستجو برای: 115
تعداد نتایج: 20602 فیلتر نتایج به سال:
We investigated the pedal rate dependency of the effect of priming exercise on pulmonary oxygen uptake (Vo(2)) kinetics. Seven healthy men completed two, 6-min bouts of high-intensity cycle exercise (separated by 6 min of rest) using different combinations of extreme pedal rates for the priming and criterion exercise bouts (i.e., 35-->35, 35-->115, 115-->35, and 115-->115 rev/min). Pulmonary ga...
CC-115, a selective dual inhibitor of the mammalian target of rapamycin (mTOR) kinase and DNA-dependent protein kinase (DNA-PK), is undergoing Phase 1 clinical studies. Here we report the characterization of DNA-PK inhibitory activity of CC-115 in cancer cell lines. CC-115 inhibits auto-phosphorylation of the catalytic subunit of DNA-PK (DNA-PKcs) at the S2056 site (pDNA-PK S2056), leading to b...
Approximately 25-40% of patients with lung cancer show bone metastasis. Bone modifying agents reduce skeletal-related events (SREs), but they do not significantly improve overall survival. Therefore, novel therapeutic approaches are urgently required. In this study, we investigated the anti-tumor effect of TAS-115, a VEGFRs and HGF receptor (MET)-targeted kinase inhibitor, in a tumor-induced bo...
Recent observation of β decay of 115 In to the first excited level of 115 Sn with an extremely low Q β value (Q β ≤ O(1) keV) could be used to set a limit on neu-trino mass. To give restriction potentially competitive with those extracted from experiments with 3 H (≃2 eV) and 187 Re (≃15 eV), atomic mass difference between 115 In and 115 Sn and energy of the first 115 Sn level should be remeasu...
Recent observation of β decay of 115 In to the first excited level of 115 Sn with an extremely low Q β value (Q β ≤ O(1) keV) could be used to set a limit on neu-trino mass. To give restriction potentially competitive with those extracted from experiments with 3 H (≃2 eV) and 187 Re (≃15 eV), atomic mass difference between 115 In and 115 Sn and energy of the first 115 Sn level should be remeasu...
Four novel oxapenem compounds (i.e., AM-112, AM-113, AM-114, and AM-115) were investigated for their beta-lactamase inhibitory activity against a panel of isolated class A, C, and D enzymes, which included expanded-spectrum beta-lactamase enzymes (ESBLs). The oxapenems were potent beta-lactamase inhibitors. Activity varied within the group, with AM-113 and AM-114 proving to be the most active c...
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