The loss of the endothelium barrier and vascular leakage play a central role in the pathogenesis of hemorrhagic fever viruses. This can be caused either directly by the viral infection and damage of the vascular endothelium, or indirectly by a dysregulated immune response resulting in an excessive activation of the endothelium. This article briefly reviews our knowledge of the importance of the...

The role of the vascular microenvironment in the pathogenesis Systemic Sclerosis (SSc) is appreciated clinically as Raynaud's syndrome with capillary nail bed change. This manifestation of vasculopathy is used diagnostically in both limited and diffuse cutaneous subsets of SSc, and is thought to precede fibrosis. The degree of subsequent fibrosis may also be determined by the vascular microenvi...

Heart and vascular diseases are responsible for tens of millions deaths annually, underscoring an urgent need to improve the existing clinical practice in order benefit patients. Advancement basic science technology enables understanding disease etiology pathogenesis at a deeper level complexity. This mini-review article provides summary recent methods cell molecular biology applicable current ...

Given the global trends in population aging, prevalence of vascular dementia (VD) is increasing year by year. VD has become second most common type and can seriously threaten quality life patients. Since preventable, it important to study clinically order improve prognosis In recent years, a large number studies have been carried out at home abroad, focusing on pathogenesis, rehabilitation asse...

Endothelial cell (EC) apoptosis and apoptosis resistant proliferation have been proposed to play crucial roles in the development of featured plexiform lesions in the pathogenesis of pulmonary hypertension (PH). Subsequently, EC injury associated smooth muscle cell (SMC) proliferation facilitates vascular remodeling and eventually leads to narrowed vascular lumen, increased pulmonary vascular r...

adenomyosis is a widespread disease affecting the reproductive period of women’s life. in the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease. this article aims to present and discuss the most important pathophysiologic mechanisms underlying adenomyosis development in order to clarify the relationship between adenomyo...