abstract       background and objective: chlamydia trachomatis is one of the most common causes of genital infection in men and women. genital chlamydial infections in women are clinically asymptomatic in 70-80% of the cases; therefore, the lack of timely diagnosis and treatment leads to complications such as infertility and ectopic pregnancy. the aim of this study was to evaluate the frequency...

objective: listeria monocytogenes is a facultative, gram-positive bacterium which is found in soil, water, decaying vegetables, raw milk, and contaminated dairies. listeria monocytogenes causes listeriosis. listeriosis is a zoonosis disease, which transfers from animals to humans by animal feces and contaminated dairies. listeriosis causes the flu like disease or self-limited enteritis, but it ...

OBJECTIVE To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to-severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy. METHODS A substudy of the REJOICE trial (multicenter, double-blind, placebo-controlled, phase 3) evaluated the pharmacokinetics of 4, 10, and 25-μg TX-004HR doses once/d for 2 weeks, followed by...

Novel experimental and theoretical methods in evaluating the systemic bioavailability of estrogens delivered via the vaginal route have been developed. The approaches were demonstrated for estrone and estradiol in the rhesus monkey. These newly developed techniques have made it possible to quantify first pass vaginal membrane metabolism for estrone and for estradiol and to disthlguish this proc...

OBJECTIVE To compare the efficacy and safety of a 200-microgram misoprostol vaginal insert with a 10-mg dinoprostone vaginal insert for reducing the time to vaginal delivery. METHODS In a phase III, double-blind, multicenter study, women being induced with a modified Bishop score of 4 or less were randomly assigned to receive either a 200-microgram misoprostol vaginal insert or a 10-mg dinopr...

BACKGROUND/AIMS There is a lack of evidence in the literature supporting vaginal application of a combination hormone-containing cream for local and systemic symptom relief. This pilot study examined the extent of absorption of a single cream containing estriol, estradiol, progesterone, DHEA, and testosterone. METHODS A combination cream was administered to 12 postmenopausal women in two diff...

the present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

background vaginitis is the most common gynecological problem and the second most common infection. this condition occurs in approximately 90% of the affected females; secondary to bacterial vaginosis and vulvovaginal candidiasis. objectives according to the high prevalence of vulvovaginal candidiasis in iran and because of the importance of controlling causing species, the current study aimed ...