Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion mammalian Indy (mIndy) gene rodents improves metabolism via mechanisms akin to caloric restriction, known blood pressure (BP) by sympathoadrenal inhibition. We hypothesized that mIndy deletion attenuates support BP. Continuous arterial BP and heart rate (...

Studies in 24 recurrent oxalate stone-formers have shown that values for urinary calcium excretion for this group on at-home diets vary significantly (P less than 0.001) more than values for creatinine excretions. By placing stone-formers on controlled in-hospital diets and measuring their calcium excretions, we were able to predict probable outpatient hypercalciuria (greater than 7.5 mmol/day)...

We have studied the ability of urinary molecules in altering the precipitation of kidney stone-related calcium oxalate monohydrate (COM) crystals and correlated the resulting morphologies with those of idiopathic COM kidney stones. We found that weakly acidic but highly glycosylated polyelectrolytes (Tamm Horsfall protein (THP), fetuinA, hyaluronic acid) do not significantly affect crystallizat...

The study was designed to assess the relationship between glomerular filtration rate (GFR) and urinary stone-forming constituents, and to assess the effect of renal insufficiency on stone recurrence risk in first stone formers (SF). Baseline serum creatinine levels were obtained, and renal insufficiency was defined as creatinine clearance ≤60 mL/min (Cockroft-Gault). This retrospective case-con...

BACKGROUND Potassium citrate (K-Cit) is one of the medications widely used in patients with urolithiasis. However, in some cases with calcium oxalate (CaOx) urolithiasis, the significant response to alkaline therapy with K-Cit alone does not occur. There is scarce published data on the effect of magnesium chloride (Mg-Cl(2)) on urolithiasis in pediatric patients. This study aimed to evaluate th...

Background: A very strict control of urinary pH is recommended to maintain it between 5.5 and 6.2, preventing formation or recurrence crystals. Kidney stones are a common problem, with high rate recurrence, not altered by the success surgery. Medical treatment prevents recurrence. Potassium Citrate inhibits crystallization calcium salts. It influences calculogenesis increasing citrates alkalini...

INTRODUCTION Nephrolithiasis is a common condition with high prevalence and recurrence, occurring by a complex and multifactorial process. OBJECTIVE To analyze the main dietary and metabolic characteristics of patients with nephrolithiasis and compare them with a control group. METHODS A cross sectional study with 31 patients with nephrolithiasis (NE) and 18 healthy. By the dietary intake i...

We have previously observed that the urinary excretion of citrate is reduced to low levels in rats treated with the carbonic anhydrase inhibitor, acetazoleamide (Diamox®g) (1). This first experiment was prompted by the fact that the elevated serum chloride and decreased serum bicar-. bonate concentrations, and the fixation of the urine pH at approximately 7 or above following administration of ...

PURPOSE To study the effects of long-term treatment with potassium magnesium citrate and vitamin B-6 prophylaxis (Urikind-KM6; 1,100-mg potassium citrate, 375-mg magnesium citrate, and 20-mg pyridoxine hydrochloride/5 mL) every 8 hours over 3 years. MATERIALS AND METHODS A total of 247 patients with recurrent idiopathic hypocitraturia with or without hyperuricosuria and randomized controls we...