background: preoperative determination of the extent of viable residual tumor is an important issue after neoadjuvant treatment. on the other hand, retrospective data suggest that breast-conserving surgery is feasible up to stage iiia breast cancer without preoperative therapy. methods: we retrospectively analyzed 164 patients who underwent breastconserving surgery followed by adjuvant chemothe...

Granular cell tumor is a rare benign non-encapsulated tumor that mostly presents in oral cavity. Breast localization is uncommon and occurs in about one per 1000 cases of breast cancers. It mainly affects premenopausal women showing the possible role of estrogen and progesterone levels in the progression of this tumor. Granular cell tumor is a great emulator of the invasive ductal carcinoma of ...

Abstract BACKGROUND Glioblastoma multiforme (GBM) remains a disease with debilitating survival outcomes. Cancer immunogenomics represents complementary approach to the application of genomics in developing novel immunotherapies for brain malignancies. Using cancer that we developed, called Open Reading Frame Antigen Network (O.R.A.N.), identified immunogenic neoantigens and tumor-associated ant...

introduction proton therapy is used to treat malignant tumors such as melanoma inside the eye. proton particles are adjusted according to various parameters such as tumor size and position and patient’s distance from the proton source. the purpose of this study was to assess absorbed doses in eyes and various tumors found in the area of sclera and choroid and the adjacent tissues in radiotherap...

Herein we report a case of primary leiomyosarcoma of testis, which was believed to originate from normal testicular structures.  It contained smooth muscle cells, blood vessels and contractile cells of the seminiferous tubules.  No evidence of tumor spread was found.Treatment consisted of orchiectomy with high ligation of the spermatic cord.  The patient received no adjuvant therapy and there w...

Photomediated immunotherapy explored to combine the anti-cancer effect of phototherapy with immune enhancement ability immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated triggered antitumor immunity through release tumor antigens damage-associated molecular patterns from necrotic cells was not enough mighty improve therapeutic benefits due immunosup...

Vestibular Schwannoma forms in Schwann cells which cover the vestibular nerve, often internal auditory canal. Symptoms were likely present before excision of tumor. After tumor, symptoms may include, hearing defects, tinnitus, facial muscle abnormalities, headache, and balance impairments. This case report is a female patient with schwannoma, who had few above-mentioned after surgery. Her physi...

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...

Chemodynamic-Photothermal Therapy In article number 2102759 by Liangliang Zhang, Shulin Zhao, Hong Liang, and co-workers, smart near infrared carbon dot-metal organic framework assemblies are developed for tumor microenvironment (TME)-activated cancer imaging chemodynamic-photothermal combined therapy.