A positive selection system designed to identify and recover candidate tumor-suppressor genes is described. The system compares mRNA expression of genes from normal and tumor-derived human mammary epithelial cells grown in a special medium that supports similar growth rates of the two cell types. mRNAs uniquely expressed in normal cells are recovered as cDNAs after subtraction with mRNA from tu...

miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miR...

Previous evolutionary study of the tumor suppressor Merlin revealed that this protein family was produced by very early metazoans with the exception of some or all flatworm lineages [Golovnina et al., 2005]. We ask whether other tumor-suppressor proteins had also been in existence in these times and focus our attention on hyperplastic discs (Hyd) protein, a classic tumor suppressor in Drosophil...

DLC1 is a candidate tumor suppressor gene recently isolated from human hepatocellular carcinoma (HCC). Structurally, DLC1 protein contains a conserved RhoGAP domain, which has been thought to regulate the activity of Rho family proteins. Previous studies indicated that DLC1 was frequently inactivated in cancer cells. In the present study, we aimed to characterize the tumor suppressor roles of D...

The phosphatidylinositol 3-kinases (PI3Ks)/protein kinase B (AKT) signaling pathway is frequently overexpressed in lung adenocarcinoma and associated with carcinogenesis through cell proliferation, apoptosis deactivation; it also enhances chemotherapeutic drugs resistance. Tualang honey (TH) has proven anticancer property on adenocarcinoma. However, the underlying mechanisms remain unreported. ...

Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the occurrence of bilateral vestibular schwannomas and other central nervous system tumors including multiple meningiomas. Genetic linkage studies and investigations of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene in chromosome 22q12. We have identified a cand...

: The liver is one of the most common sites metastatic spread lung cancer, and process metastasis regulated by many factors. A number genes, including multiple tumor suppressor 1 (mts1), p120 catenin, CT45A1, increase possibility hepatic in whereas Tip30/CC3, CUL5, SOCS3 expression tumors inhibit metastasis. microRNAs (miRNAs), such as miRNA-126, miRNA-338, miRNA-218, can affect cancer cells to...

The products of the tumor suppressor genes are considered to function as specific inhibitors of tumor cell growth. In this communication, we present evidence to show that these proteins inhibit tumor cell proliferation by participating in the activation of tumor cell differentiation. The ML-1 human myeloblastic leukemia cells used in this study proliferate when treated with insulin-like growth ...

The products of the tumor suppressor genes are considered to function as specific inhibitors of tumor cell growth. In this communication, we present evidence to show that these proteins inhibit tumor cell prolifera tion by participating in the activation of tumor cell differentiation. The MI -I human myeloblastic leukemia cells used in this study proliferate when treated with insulin-like growt...