BACKGROUND Painful diabetic neuropathy (PDN) is a serious complication of diabetes mellitus that affects a large number of patients in many countries. The molecular mechanisms underlying the exaggerated nociception in PDN have not been established. Recently, duloxetine (DLX), a serotonin and noradrenaline re-uptake inhibitor, has been recommended as one of the first-line treatments of PDN in th...

BACKGROUND Free radical formation and oxidative stress might play an important role in the pathogenesis of Parkinson's disease (PD). In vitro data indicate that neuromelanin (NM) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (VMAT2). We designed this study to investigate the neuroprotective effects o...

with the aim of reducing cost of electricity consumption and peak load reduction, tools requirement for better managing electricity consumption have become inevitable in recent years. smart home has some equipment which are controllable and this ability is used for increasing comfort and minimizing electricity cost for residence. as a key component of smart home , electric vehicle(ev) ,increase...

nowadays, the use of small vehicles is spreading among urban areas and one sort of these vehicles are three-wheeled vehicles (twvs) which can be competitive with four-wheeled urban vehicles (fwvs) in aspects such as smallness, simple manufacturing, and low tire rolling resistance, fuel consumption and so on. the most critical instability associated with twvs is the roll over. in this paper a ti...

background: ritalin has high tendency to be abused. it has been the main indication to control attention deficit hyperactivity disorder. the college students may seek for it to improve their memory, decrease the need for sleep (especially during exams), which at least partially, can be related to serotonergic system. therefore, it seems worthy to evaluate the effect of ritalin intake on mature ...

the capacitated vehicle routing problem (cvrp) is a well-known combinatorial optimization problem that holds a central place in logistics management. the vehicle routing is an applied task in the industrial transportation for which an optimal solution will lead us to better services, save more time and ultimately increase in customer satisfaction. this problem is classified into np-hard problem...

among numerous np-hard problems, the traveling salesman problem (tsp) has been one of the most explored, yet unknown one. even a minor modification changes the problem’s status, calling for a different solution. the generalized traveling salesman problem (gtsp)expands the tsp to a much more complicated form, replacing single nodes with a group or cluster of nodes, where the objective is to fi...

the suspension system of a vehicle is one of the most important parts which is involved in the process of vehicle designing. when a vehicle suspension system is designed, the evaluation of its performance against the road disturbances such as shocks and bumps are very important. the most commonly used systems consist of four hydraulic jacks with mobility in vertical line with low speed and low ...

objective: recent studies suggest that intermittent and prolonged normobaric hyperoxia (ho) results in ischemic tolerance to preventing ischemia brain injury. in this research attempts were made to see the changes in excitatory amio-acid transporter 3 (eaat3), tnf-α levels, and nf-κb activity following prolonged and intermittent nbho preconditioning. materials and methods: rats were divided i...