نتایج جستجو برای: toxicological assessment
تعداد نتایج: 568515 فیلتر نتایج به سال:
Microarray technologies have both fascinated and frustrated the toxicological community since their introduction around a decade ago. Fascination arose from the possibility offered by the technology to gain a profound insight into the cellular response to chemically mediated stress, and the potential that this genomic signature would be indicative of the biological mechanism by which that stres...
Hormesis, a dose-response phenomenon characterized by a low-dose stimulation and a high-dose inhibition, has been the object of controversy due to its challenging of basic understandings of the dose-response relationship and implications for risk assessment. The author addresses issues relating to the definition of hormesis, the relationship of hormesis to risk assessment and risk management, a...
The low-dose effect and non-monotonicity hypotheses challenge key concepts in eco-toxicology and risk assessment, and also the possibility to predict the effects of a chemical at low levels of exposure from its effects at higher levels of exposure. Low-dose effects and Non-Monotonic Dose-response Curves (NMDRC) provides situations to understand impacts for toxicological risk assessment paradigm...
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of various food additives, with a view to recommending acceptable daily intakes (ADIs) and to preparing specifications for identity and purity. The first part of the report contains a general discussion of the principles governing the toxicological evaluation and assessment of intake of fo...
The SAB should be aware that the process of risk assessment within the federal agencies has at least a 30-year history (the NRC “Red Book” was published in 1983) and has undergone much review. While US EPA is one of the leading federal agencies in the evolution of toxicological risk assessments, the appropriate venue for making significant changes to the risk assessment process should include t...
background: this toxicological investigation involves a report on the death of four occupants of a sport utility vehicle on one of the major busy federal roads of nigeria where they were held for up to three hours in a traffic jam while the car was steaming. methods: autopsy was executed using the standard procedure and toxicological analysis was done using simple spectrophotometric method ...
In vitro toxicological tests have been proposed as an approach to complement the chemical safety assessment of food contact materials, particularly those with a complex or unknown chemical composition such as paper and board. Among the concerns raised regarding the applicability of in vitro tests are the effects of interference of the extractables on the outcome of the cytotoxicity and genotoxi...
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