Constitutive Hedgehog (HH) signaling underlies several human tumors, including basal cell carcinoma (BCC). Recently, Bijlsma and colleagues reported a new biologic function for vitamin D3 in suppressing HH signaling in an in vitro model system. On the basis of that work, we have assessed effects of vitamin D3 on HH signaling and proliferation of murine BCCs in vitro and in vivo. We find that in...

Abstract Introduction Platelet-rich plasma (PRP) has gathered great momentum in surgery. The main outcome of the study was to assess whether there a difference growth factor release from PRP with addition vitamin C, cooling, or both C and cooling. Method Blood samples 10 volunteers were centrifuged produce PRP. Activated autologous thrombin produced platelet-poor (PPP), which added activate it....

Mild to moderate psoriasis is a disease that can often be treated with topical medications. The diversity of topical therapies and their disparate side effects complicates treatment planning. Our purpose is to compare the rates of adverse events associated with different topical psoriasis treatments. A review of medical literature from 1996 to March, 2002 was conducted using guidelines set by Q...

Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation immature melanocytes, and melanocyte activity. The use vitamin dermatology is treatment vitiligo, psoriasis vulgaris, atopic dermatitis, verruca alopecia. Vitiligo an autoimmune disease skin form depigmentation due to destruction melanocytes by T cells. clinical manifestations vitili...

DNA damage caused by ultraviolet (UV) irradiation is considered the main etiologic factor contributing to the development of skin cancer. Systemic or topical application of antioxidants has been suggested as a protective measure against UV-induced skin damage. We investigated the effect of long-term oral administration of a combination of the antioxidants ascorbic acid (vitamin C) and D-alpha-t...

introduction: iron deficiency anemia (ida) is the most common form of anemia and one of the most important health problems. iron supplementation for high risk groups can prevent ida and its complications in the community. we need to have a holistic approach to control ida with minimum cost and complications. considering the high prevalence rate of ida in iran, assessment of the effects of micro...

background: the aim of this study is to investigate the effect of vitamin a and c, as the agents that improve wound healing, on the adhesion formation process. materials and methods: sixty male wistar rats were used. they underwent midline laparotomy, for repair of a peritoneal injury, and were then assigned to four groups. group 1 (vitamin a) received 2000 units/kg intramuscular injection of v...

BACKGROUND Treatment of brown recluse spider bites remains controversial; there are multiple options but little evidence of their effectiveness. METHODS Over a 5-year period, family physicians enrolled consecutive patients with suspected brown recluse spider bites. Usual care was provided based on physician preferences. Topical nitroglycerine patches and vitamin C tablets were provided at no ...