Acylglucuronides formed from carboxylic acids by UDP-glucuronosyltransferases (UGTs) are electrophilic metabolites able to covalently bind proteins. In this study, we demonstrate the reactivity of the acylglucuronide from the nonsteroidal antiinflammatory drug, ketoprofen, toward human and rat liver UGTs. Ketoprofen acylglucuronide irreversibly inhibited the glucuronidation of 1-naphthol and 2-...

During an investigation of the in vitro glucuronidation of benoxaprofen by human liver S-9 fraction, an unusual drug-related entity possessing a protonated molecular ion that was 74 mass units greater than the parent drug was observed. It was identified as the glycerol ester of benoxaprofen. Formation of this entity required inclusion of uridine diphosphoglucuronic acid (UDPGA) in the incubatio...

Sir, Acute interstitial nephritis associated with nephrotic syndrome has been reported with the use of different drugs: nonsteroidal anti-inflammatory drugs (NSAIDS), antibiotics, lithium, interferon, etc. However, this clinical syndrome is very rare (55 cases were reported in world literature in 1988) [1]. Moreover, after withdrawal of the drug, a total or at least partial recovery of renal fu...