Hormones have to be transported from their sites of synthesis to their target organs. For lipophilic hormones, such as steroids and thyroid hormones, transport is accomplished by binding to specific serum proteins, in the case of thyroxine (T4) and tri-iodothyronine (T3) to thyroxine-binding globulin (TBG) and prealbumin (PA). Normally about 70% of circulating T4 and 7540% of T3 is bound to TBG...

The function of the thyroid gland is to synthesize the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroid cells are the only cells in the body that can absorb the element iodine, which can be found in many foods. These cells combine iodine and the amino acid, tyrosine, to produce T3 and T4. The T3 and T4 hormones are then released into the bloodstream and are transported through...

Abstract Background Adult-onset hypothyroidism has a deleterious effect on hippocampal cognitive and memory functions. This study was performed to evaluate the possible therapeutic of thyroxine hippocampus degeneration in an adult male rat model carbimazole-induced potentiality spontaneous recovery. Thirty-two albino rats were divided equally into four groups, as follows: I (control group), II ...

Despite some early doubts concerning its presence in plasma and its physiological function (1-4), the thyroxine-binding prealbumin of human serum (TBPA) is now known to play a significant role in the transport of thyroxine (T4) (5-8). Normally, as assessed by in vitro techniques, TBPA appears to bind at least 25 to 35%o of T4 in serum (5, 6). In the serum of many patients with severe acute or c...

Electroencephalographic activity (EEG) of pre-optic area (POA) was recorded after intracerebroventricular (ICV) microinjection of thyroxine (T4) and thyrotropin (TSH) in conscious male dogs. Recordings were made for two hours following microinjections. Biphasic responses with increased amplitude were observed in both the treatments, but chronologically the responses obtained with T4 & TSH were ...

Despite some early doubts concerning its presence in plasma and its physiological function (1-4), the thyroxine-binding prealbumin of human serum (TBPA) is now known to play a significant role in the transport of thyroxine (T4) (5-8). Normally, as assessed by in vitro techniques, TBPA appears to bind at least 25 to 35%o of T4 in serum (5, 6). In the serum of many patients with severe acute or c...

Polybrominated diphenyl ethers (PBDEs) have been shown to disrupt thyroid hormone (TH) functions on experimental animals, and one of the proposed disruption mechanisms is the competitive binding of PBDE metabolites to TH transport proteins. In this report, a nonradioactive, site-specific fluorescein-thyroxine (F-T4) conjugate was designed and synthesized as a fluorescence probe to study the bin...