Free radicals are all known to damage cell components. The present study was designed to evaluate the free radical generation in the testis and liver and also to determine the testicular and hepatic antioxidant enzyme activities with and without catechin administration in thyroxine induced male Sprague-Dawley rats. The experimental animals were divided into four groups, six on each division. L-...

Thyroxine(T4)-binding to serum proteins in primates; catarrhini, prosimiae, and platyrrhini were studied by polyacrylamide gel electrophoresis T4 binding analysis. From the electrophoretic analysis, it was shown that thyroxine-binding proteins similar to human thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA) were present in catarrhini and prosimiae species, but not in pl...

Brien, T. G., Fay, J. A., and Griffin, E. A. (1974). Archives of Disease in Childhood, 49, 225. Thyroid status in the newborn infant: effective thyroxine ratio and free thyroxine index. The effective thyroxine ratio (ETR) was determined in 28 term and 17 premature infants at birth and in 17 infants aged 0 to 6 weeks. The mean values found were significantly higher than those in 20 adult euthyro...

Hypothyroidism is an extremely common condition. More than 100 million prescriptions for thyroxine (T4) are processed in the USA each year. T4 recommended treatment hypothyroidism. But 5-15% of patients treated to target with continue have symptoms.

In one case of untreated Hashimoto's thyroiditis, the serum thyroxine (T4) value, obtained by radioimmunoassay (RIA) employing resin to separate bound and free T4, was significantly lower than that obtained by competitive protein binding analysis (CPBA). The discrepancy was found to be due to the presence of anti-thyroxine autoantibody in the serum. This phenomenon is considered to be of practi...

Serum concentrations of T4, T3, rT3, and TSH were measured by radioimmunoassay in 45 patients suffering from beta-thalassaemia. A TRH stimulation test was performed and the binding capacity of TBG and TBPA for T3 and T4 measured by reverse flow zone electrophoresis in a group of these patients. Mean T4 serum concentration was lower in thalassaemic patients than controls; T3, rT3, TSH levels, an...

on thyroxine-binding proteins (UTBP), T4 bound to thyroxine-binding proteins (PBI or TBPT4) andfree thyroxine (FT4). thyroid status. This is shown in diagrammatic fashion in fig 1 which illustrates the changes that occur in thyrotoxicosis and hypothyroidism and in those situations where there are alterations in thyroxine-binding protein capacity, such as the increase in thyroxine-binding globul...

To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine (T3) were carried out in eight subjects with familial dysalbuminemic hyperthyroxinemia (FDH), in four subjects with inherited TBG excess, and in 15 normals. In high-TBG subjects, the reduction ...

introduction: previous studies have shown that ghrelin inhibits the activity of hypothalamus –pituitary – thyroid (h–p-t) axis. it is also proved that ghrelin increases appetite via agouti related protein and neuropeptide y pathway, decreases t3 & t4 secretion and inhibits serotonin release from hypothalamic synaptosomes. serotonin may interact with ghrelin in control of thyroid hormones secret...