. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cardiac-specific mindin overexpress...

CGS: cutaneous granulocytic sarcoma GS: granulocytic sarcoma IHC: immunohistochemistry KP: Koebner phenomenon MDS: myelodysplastic syndrome MPO: myeloperoxidase PG: pyoderma gangrenosum TGF-b1: transforming growth factor-beta 1 TGF-b1R: transforming growth factor-beta 1 receptor INTRODUCTION Granulocytic sarcoma (GS) is also known as myeloid sarcoma or chloroma because of its green hue caused b...

MicroRNAs (miRNAs) are important regulators of the human transcriptome, and their role in multiple physiological processes has been well established. Likewise, the participation of these small noncoding RNAs in various pathological states, including cancer, is now fully recognized. Nonetheless, in many instances, the breadth of the dysfunction caused bymiRNA deregulation is not entirely known. ...

Backgroud: Idiopathic pulmonary fibrosis is a devastating disorder for which there is no effective treatment. Transforming growth factor (TGF)-b plays a critical role in provoking fibrosis. Interleukin (IL)-10 is a potent immunosuppressive cytokine but its effect on the fibrosing process is unclear. A study was undertaken to examine whether IL-10 affects the production and activation of TGF-b a...

Backgroud: Idiopathic pulmonary fibrosis is a devastating disorder for which there is no effective treatment. Transforming growth factor (TGF)-b plays a critical role in provoking fibrosis. Interleukin (IL)-10 is a potent immunosuppressive cytokine but its effect on the fibrosing process is unclear. A study was undertaken to examine whether IL-10 affects the production and activation of TGF-b a...

The present study was designed to investigate the growth regulatory effects of cytokines in UT-OC-3 ovarian cystadenocarcinoma cells in vitro. The effects of interleukin-6 (IL-6), interferons a (IFN-a) and g (IFN-g), granulocyte-macrophage colony-stimulating factor (GM-CSF), tumour necrosis factor a (TNF-a), and transforming growth factor b1 (TGF-b1) were investigated by I-deoxyuridine (IUdR) i...

Elastin, an extracellular component of arteries, lung, and skin, is produced during fetal and neonatal growth. We reported previously that the cessation of elastin production is controlled by a posttranscriptional mechanism. Although tropoelastin pre-mRNA is transcribed at the same rate in neonates and adults, marked instability of the fully processed transcript bars protein production in matur...

Studies have demonstrated that local angiotensin II (Ang II) generation is enhanced in repairing kidney and that ACE inhibition or AT1 receptor blockade attenuates renal fibrosis. The localization of ACE and Ang II receptors and their relationship to collagen synthesis in the injured kidney, however, remain uncertain. Using a rat model of renal injury with subsequent fibrosis created with chron...

Citation: Chen T-C, Chang S-W. Moxifloxacin modulated TGF-b1-related interleukin-12 secretion in corneal fibroblasts. Invest Ophthalmol Vis Sci. 2017;58:5692–5702. DOI:10.1167/ iovs.17-21944 PURPOSE. To explore the variability in interleukin-12 (IL-12) secretion in human corneal fibroblasts (HCFs), the effects of IL-12 on HCF viability and migration, and the effects of recombinant human transfo...

Transforming growth factor-B (TGF-B) inhibits the proliferation of carcinomas in early stages of breast cancer, whereas it promotes tumor growth and metastasis in later stages of cancer. We evaluated a possible association between TGF-b1 gene polymorphisms and breast cancer risk in a populationbased case-control study of Chinese women living in Shanghai, which included 1,127 breast cancer cases...