نتایج جستجو برای: steatohepatitis
تعداد نتایج: 8373 فیلتر نتایج به سال:
Mechanobiology is a rapidly emerging field focused on the biological impact of physical forces at molecular, cellular, and tissue level. Living cells perceive mechanical cues transform them into biochemical signals through mechanotransduction. Mechanotransduction complex process that involves mechanosensors (which are located in plasma membrane or within cell) mechanotransmission to nucleus occ...
Over the past decades, many drugs have been identified, that can potentially induce steatohepatitis in the predisposed individual. Classically this has been incriminated to amiodarone, perhexiline, and 4,4'-diethylaminoethoxyhexestrol (DH), all of which have been found to independently induce the histologic picture of non-alcoholic steatohepatitis (NASH). Pathogenetic mechanisms of hepatotoxici...
Non-alcoholic fatty liver disease (NAFLD) is a slowly progressive chronic disease, with a high prevalence among obese, dyslipidemic or diabetic people, commonly presented as an asymptomatic mild elevation of serum aminotransferases. We report a patient who experienced an acute form of non-alcoholic steatohepatitis, as the first manifestation of NAFLD, due to exacerbation of pre-existing metabol...
Dubin-Johnson syndrome (DJS) is a benign autosomal recessive liver disorder characterised by an intermittent jaundice caused by chronic and conjugated hyperbilirubinaemia. Many mutations in multidrug resistance associated protein (MRP-2) gene have been identified in patients with DJS. Although the disease is usually asymptomatic, some patients may experience vague abdominal pain. In this report...
Background: Progressive familial intrahepatic cholestasis is a disease presenting with severe and progressing to the end-stage liver later. Liver transplantation treatment modality available for progressive cholestasis, especially in patients or those who are unsuitable have failed biliary diversion. Objectives: To evaluate clinical pathological characteristics of had undergone determine post-t...
Non-alcoholic steatohepatitis (NASH) is becoming a growing public health problem along with the increase of metabolic syndrome worldwide. Extracellular nucleotides are known to serve as danger signal by initiating purinergic signaling in many inflammatory disorders, although role progression NASH remains be clarified. Vesicular nucleotide transporter (VNUT) key molecule responsible for vesicula...
background: nonalcoholic fatty liver disease (nafld) includes a group of chronic liver disorders caused by irregular accumulation of fat in liver tissue. the current study aimed to evaluate chemical composition and the effect of fruit extract and essential oil of pimpinella anisum in experimental model of nafld. materials and methods: sixty rats were randomly divided into ten groups, six in eac...
Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) cause significant morbidity and mortality in affected patients and are common causes of liver failure worldwide [1]. NAFLD and ALD are histologically indistinguishable by conventional methods but their disease courses are quite divergent. In particular, ALD patients with steatohepatitis have a more rapid progression to ...
In previous studies, the relationship between aspartate aminotransferase to alanine aminotransferase ratio(AST/ALT ratio) and liver disease has been evaluated. In viral hepatitis, alcoholic liver disease and primary biliary cirrhosis, AST/ALT ratio has been proven to be an indicator of liver cirrhosis.1-3 AST/ALT ratio was a potential value in differentiating nonalcoholic steatohepatitis from a...
There is a need, in NAFLD management, to develop non-invasive methods to detect steatohepatitis (NASH) and to predict advanced fibrosis stages. We evaluated a tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance (MR) protocols using 1.5T General El...
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