aim : to investigate association between mthfr gene polymorphism with colorectal cancer. background : the enzyme 5,10-methylene-tetrahydrofolate reductase (mthfr) is linked to dna methylation, synthesis and repair. one of the most important polymorphisms that has been identified in the mthfr gene is c677t. the single nucleotide polymorphism c677t has been found to be associated with decreased e...

let $g$ be a finite group‎. ‎we say that $g$ has emph{spread} r if for any set of distinct non-trivial elements of $g$ $x:={x_1,ldots‎, ‎x_r}subset g^{#}$ there exists an element $yin g$ with the property that $langle x_i,yrangle=g$ for every $1leq ileq r$‎. ‎we say $g$ has emph{exact spread} $r$ if $g$ has spread $r$ but not $r+1$‎. ‎the spreads of finite simple groups and their decorations ha...

To understand genetic and epigenetic pathways in Wilms' tumors, we carried out a genome scan for loss of heterozygosity (LOH) using Affymetrix 10K single nucleotide polymorphism (SNP) chips and supplemented the data with karyotype information. To score loss of imprinting (LOI) of the IGF2 gene, we assessed DNA methylation of the H19 5' differentially methylated region (DMR). Few chromosomal reg...

Abstract Lakes are an important ecosystem component and geomorphological agent in northern high latitudes it is to understand how lake initiation, expansion drainage may change as continue warm. In this study, we utilized Landsat Multispectral Scanner System images from the 1970s (1972, 1974, 1975) Operational Land Imager 2010s (2013, 2014, 2015) assess broad-scale distribution changes of lakes...

abstract information on reduviidae species are sporadic and very rare in iran due to the few survey conducted on this bugs. a study was done to determine the diversity of this family during 2008 - 2009. several species were collected among them holotrichius mesoleucus (kiritshenko, 1914) was found to be the species recorded for the first time in iran. this species was collected from avena fatua...

The molecular genetics of inherited phaeochromocytoma have received considerable attention, but the somatic genetic and epigenetic events that characterise tumourigenesis in sporadic phaeochromocytomas are less well defined. Previously, we found considerable overlap between patterns of promoter region tumour suppressor gene (TSG) hypermethylation in two neural crest tumours, neuroblastoma and p...

approximately 5-10% of all thyroid cancers are medullary thyroid carcinomas (mtc). mtc is mainly sporadic in nature, but 20-30% of cases are hereditary. genetic testing for hereditary mtc is very important for the patient and his family, but the patients must be receiving appropriate genetic counseling. about 98% of patients with hereditary mtc have germline mutations in exons 10, 11, 13, 14, 1...

Heat Shock Cognate 70 (HSC70) is a constitutively expressed molecular chaperone, functions of which regulate the structure, subcellular localization, and turnover of cell proteins. It is also a component of the centrosome facilitating rearrangements during mitotic/meiotic spindle formation and cytoplasmic microtubule organization. We localized HSC70 to 11q23.3, a region deleted in 40% of sporad...

Juvenile nephronophthisis (NPH) is a genetically heterogeneous disorder representing the most frequent inherited cause of chronic renal failure in children. We recently assigned a gene (NPH1) to the 2q13 region which is responsible for approximately 85% of cases. Cloning this region in a yeast artificial chromosome contig revealed the presence of low copy repeats. Large-scale rearrangements wer...