a rare case of splenic harmartoma in a 31 year old female is reported. she was admitted with splenomegaly, fever and chronic history of epistaxis. routine hematological survey revealed pancytopenia and mild hypercellular marrow. abdominal sonography showed a space-occupying lesion in the spleen which was suspected as malignant tumor. splenectomy was performed and histologic findings were diagno...

littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. this report describes a case of littoral cell angioma with no malignant histological features. the lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. immunohistochemically, the...

Background: Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in cell death. The aim of this study was to investigate the protective effects of sulfated derivatives of neutral polysaccharides extracted from Auricularia auricular (SNAAP). Materials and Methods: Whole blood samples from healthy donors treated with SNAAP at differen...

Abstract Sesamolin is one of the lignans derived from sesame oil. It has demonstrated significant antioxidant, anti-aging, and anti-mutagenic properties. also reportedly augments natural killer (NK) cell lysis activity. We previously reported that sesamolin exerts anticancer effects in vitro induces enhanced NK cytolytic activity against tumor cells. Herein, we aimed to determine mechanism by w...

Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer's patch development, identifying LTo as a key stromal populati...

Spleen is known to contain multiple dendritic and myeloid cell subsets, distinguishable on the basis of phenotype, function and anatomical location. As a result of recent intensive flow cytometric analyses, splenic dendritic cell (DC) subsets are now better characterized than other myeloid subsets. In order to identify and fully characterize a novel splenic subset termed "L-DC" in relation to o...

BACKGROUND Littoral cell angioma (LCA) is a recently described primary vascular neoplasm of the spleen that may be associated with other malignancies and may itself also have malignant potential. CASE PRESENTATION We present a case of LCA that was discovered incidentally in a 52-year-old woman who presented with biliary colic at the time of consultation for cholecystectomy. This vascular neop...

The spleen has the same relationship to the circulatory system that the lymph nodes have to the lymphatic system. A wide range of diseases can affect the spleen. Pathologic conditions of the spleen can be classified into the following categories: congenital diseases (accessory spleen, polysplenia, and asplenia); trauma; inflammation (abscess, candidiasis, histoplasmosis, and sarcoidosis); vascu...

We report a case of multilobated B-cell lymphoma presenting with primary splenic involvement. This is a very unusual tumour occurring in an uncommon site.