نتایج جستجو برای: sod1

تعداد نتایج: 2754  

2013
Qing Gu Tienan Feng Han Cao Yiting Tang Xin Ge Judong Luo Jiao Xue Jinyong Wu Hongying Yang Shuyu Zhang Jianping Cao

BACKGROUND Radiation-induced skin injury remains a serious concern during radiotherapy. Cu/Zn-superoxide dismutase (Cu/Zn-SOD, SOD1) is a conserved enzyme for scavenging superoxide radical in cells. Because of the integrity of cell membranes, exogenous molecule is not able to be incorporated into cells, which limited the application of natural SOD1. The aim of this study was to evaluate the pro...

2011
Yoko Okamoto Yoshitomo Shirakashi Masafumi Ihara Makoto Urushitani Miki Oono Yasuhiro Kawamoto Hirofumi Yamashita Shun Shimohama Shinsuke Kato Asao Hirano Hidekazu Tomimoto Hidefumi Ito Ryosuke Takahashi

BACKGROUND AND PURPOSE Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. In our recent studies, 14-3-3 proteins have been found in the ubiquitinated inclusions inside the anterior horn cells of spinal cords with sporadic amyotrophic lateral sclero...

Journal: :Cell 2013
Amit R. Reddi Valeria C. Culotta

Cu/Zn superoxide dismutase (SOD1) is an abundant enzyme that has been best studied as a regulator of antioxidant defense. Using the yeast Saccharomyces cerevisiae, we report that SOD1 transmits signals from oxygen and glucose to repress respiration. The mechanism involves SOD1-mediated stabilization of two casein kinase 1-gamma (CK1γ) homologs, Yck1p and Yck2p, required for respiratory repressi...

Journal: :Neuron 2015
Adrian Israelson Dara Ditsworth Shuying Sun SungWon Song Jason Liang Marian Hruska-Plochan Melissa McAlonis-Downes Salah Abu-Hamad Guy Zoltsman Tom Shani Marcus Maldonado Anh Bui Michael Navarro Huilin Zhou Martin Marsala Brian K. Kaspar Sandrine Da Cruz Don W. Cleveland

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by loss of motor neurons and accompanied by accumulation of misfolded SOD1 onto the cytoplasmic faces of intracellular organelles, including mitochondria and the endoplasmic reticulum (ER). Using inhibition of misfolded SOD1 deposition onto mitochondria as an assay, a ch...

Journal: :Structure 2016
James M Fay Cheng Zhu Elizabeth A Proctor Yazhong Tao Wenjun Cui Hengming Ke Nikolay V Dokholyan

The majority of amyotrophic lateral sclerosis (ALS)-related mutations in the enzyme Cu,Zn superoxide dismutase (SOD1), as well as a post-translational modification, glutathionylation, destabilize the protein and lead to a misfolded oligomer that is toxic to motor neurons. The biophysical role of another physiological SOD1 modification, T2-phosphorylation, has remained a mystery. Here, we find t...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Ilias G Kirkinezos Sandra R Bacman Dayami Hernandez Jose Oca-Cossio Laura J Arias Miguel A Perez-Pinzon Walter G Bradley Carlos T Moraes

A "gain-of-function" toxic property of mutant Cu-Zn superoxide dismutase 1 (SOD1) is involved in the pathogenesis of some familial cases of amyotrophic lateral sclerosis (ALS). Expression of a mutant form of the human SOD1 gene in mice causes a degeneration of motor neurons, leading to progressive muscle weakness and hindlimb paralysis. Transgenic mice overexpressing a mutant human SOD1 gene (G...

2012
Lei Pan Yasuhiro Yoshii Asako Otomo Haruko Ogawa Yasuo Iwasaki Hui-Fang Shang Shinji Hadano

Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of fatal neurodegenerative diseases characterized by a selective loss of motor neurons in the brain and spinal cord. Creation of transgenic mice expressing mutant Cu/Zn superoxide dismutase (SOD1), as ALS models, has made an enormous impact on progress of the ALS studies. Recently, it has been recognized that genetic background and ge...

2017
Dale J. Lange Mona Shahbazi Vincenzo Silani Albert C. Ludolph Jochen H. Weishaupt Senda Ajroud‐Driss Kara G. Fields Rahul Remanan Stanley H. Appel Claudia Morelli Alberto Doretti Luca Maderna Stefano Messina Ulrike Weiland Stefan L. Marklund Peter M. Andersen

OBJECTIVE Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose-dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in...

2015
Elisabeth Dirren Julianne Aebischer Cylia Rochat Christopher Towne Bernard L Schneider Patrick Aebischer

OBJECTIVE Amyotrophic lateral sclerosis is an incurable disorder mainly characterized by motoneuron degeneration. Mutations in the superoxide dismutase 1 (SOD1) gene account for 20% of familial forms of the disease. Mutant SOD1 exerts multiple pathogenic effects through the gain of toxic properties in both neurons and glial cells. Here, we compare AAV-based gene therapy suppressing expression o...

Journal: :Journal of molecular biology 2011
Elizabeth A Proctor Feng Ding Nikolay V Dokholyan

Aggregation of Cu,Zn superoxide dismutase (SOD1) is implicated in amyotrophic lateral sclerosis. Glutathionylation and phosphorylation of SOD1 is omnipresent in the human body, even in healthy individuals, and has been shown to increase SOD1 dimer dissociation, which is the first step on the pathway toward SOD1 aggregation. We found that post-translational modification of SOD1, especially gluta...

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