polyclonal anti-thymocyte globulin (atg) is used as an immunosuppressive agent in the treatment of aplastic anemia (aa). serum sickness is a recognized side effect of atg. we observed abnormal skin manifestation in patient with aplastic anemia who had been treated with atg. we conclude that abnormal immune function caused by aplastic anemia and atg and corticosteroids may aggravate the signs of...

Paroxysmal nocturnal hemoglobinuria is caused by expansion of a hematopoietic stem cell clone with an acquired somatic mutation in the PIG-A gene. This mutation aborts the synthesis and expression of the glycosylphosphatidylinositol anchor proteins CD55 and CD59 on the surface of blood cells, thereby making them more susceptible to complement-mediated damage. A spectrum of disorders occurs in P...

Background: Aplastic anemia is a rare but serious disorder. More than 70% cases of anemia are idiopathic. This study was conducted to find out the possible etiological factors in our set up. Methodology: This descriptive study was carried out in Department of Medicine, Khyber Teaching Hospital, Peshawar from January, 2005 to December, 2009. One hundred patients with acquired aplastic anemia wer...

Bone marrow failure syndromes (BMFS) are a cluster of inherited or acquired disorders characterized by peripheral cytopenia due to a decrease in hematopoietic progenitors or dysregulated hematopoiesis. Inherited bone marrow failure syndromes are mainly found in pediatric group, encompassing Diamond Blackfan anemia (DBA), Fanconi anemia (FA), congenital sideroblastic anemia (CSA), congenital neu...

Human parvovirus B19 (PV-B19) causes erythema infectiosum, hydrops fetalis, and transient aplastic crisis in immunocompromised patients with chronic hemolytic anemia, arthralgia, and chronic pure red cell aplasia [1]. It may also cause autoimmune hemolytic anemia [2] (which presents as aplastic crisis with reticulocytopenia or increased erythropoiesis with reticulocytosis) [3], autoimmune throm...

Hepatitis associated aplastic anemia (HAAA) is a well documented entity. The disorder mainly affects children and young adults. Pancytopenia is usually noted within 2-6 months time after an acute attack of hepatitis. Most cases have been described in association with hepatitis A or hepatitis C Virus. The report describes, an unusual case of acquired aplastic anemia in a patient with hemophilia ...