BACKGROUND Beta Thalassemia is the most common chronic hemolytic anemia in Egypt (85.1%) with an estimated carrier rate of 9-10.2%. Injury to the liver, whether acute or chronic, eventually results in an increase in serum concentrations of Alanine transaminase (ALT) and Aspartate transaminase (AST). AIM Evaluating the potentiating effect of iron overload & viral hepatitis infection on the liv...

OBJECTIVES Serum alanine aminotransferase (ALT) levels are sometimes used to identify patients with progressive liver disease in chronic hepatitis C. We assessed the predictive value of serum ALT at various cut-off levels, for the identification of liver disease severity. PATIENTS AND METHODS This cross sectional study was carried out at Ziauddin University and Pakistan Medical Research Counc...

BACKGROUND The aim of this study was to evaluate the associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with metabolic syndrome (MetS) in the general Chinese population. METHODS This study was a multicenter, cross-sectional study which was conducted in rural areas of China from the 2012 to 2013 Northeast China Rural Cardiovascular Health Study (NCRCHS), a...

Serum alanine aminotransferase (ALT) and aspartate aminotransfarese levels and AST/ALT ratio in 28 alcoholic and 26 nonalcoholic cases suffering from acute uncomplicated anicteric plasmodium falciparum malaria, age ranging from 18-70 years of both sexes. No. Of males and females were 18 and 10 in alcoholic uncomplicated falciparum malaria and 14 & 12 in non-alcoholic uncomplicated falciparum ma...

BACKGROUND Studies on the combined associations of elevated serum hepatic enzyme activity and alcohol drinking with metabolic syndrome are rare. Our objectives were to evaluate the associations of elevated serum hepatic enzyme activity with the prevalence of metabolic syndrome in the general Japanese population and whether alcohol drinking had a modifying effect on these associations. METHODS...

BACKGROUND Elevated alanine aminotransferase (ALT) levels may be associated with metabolic syndrome and cardiovascular diseases. This study aimed to investigate the association between elevated ALT levels and cardiometabolic risk factors in a rural Chinese population. METHODS This was a cross-sectional study conducted from July 2012 to August 2013, including 11,573 subjects (5,357 men and 6,2...

Objective: To assess association of pretreatment liver histology with serum Alanine aminotrasferase (ALT) level and Body Mass Index (BMI) in HCV positive patients. Material and Methods: A prospective study conducted at Pathology and Gastroenterology Departments of CMH Peshawar from June 2007 to December 2008 included 100 adult HCV RNA positive patients. Percutaneous liver biopsy was performed a...

AIM Elevation of alanine aminotransferase (ALT) level is commonly seen among patients suffering from severe acute respiratory syndrome (SARS). We report the progression and clinical significance of liver derangement in a large cohort of SARS patient. METHODS Serial assay of serum ALT was followed in patients who fulfilled the WHO criteria of SARS. Those with elevated ALT were compared with th...

BACKGROUND The purpose of this study was to investigate the incidence and demographic/clinical factors of alanine aminotransferase (ALT) abnormalities at the end of treatment (EOT) in chronic hepatitis C (CHC) patients with sustained virologic response (SVR). METHODS AND FINDINGS Seven hundred naïve CHC patients who underwent combination treatment between January 2003 and December 2010 were i...