Rotenone is a pesticide that is widely used to kill insects and nuisance fish in lakes. Its used as Parkinson’s Disease (PD) model inducer. The mechanism of toxicity of rotenone is primarily mediated by its potential as mitochondrial complex I inhibition. Centella asiatica (CA) is known as neurotonic, but how its potential protection in Parkinsonism is still unclear. In this study, we examined ...

Rotenone, a common pesticide and inhibitor of mitochondrial complex I, induces microglial activation and loss of dopaminergic neurons in models of Parkinson's disease. However, the mechanisms of rotenone neurotoxicity are still poorly defined. Here, we used primary neuronal/glial cultures prepared from rat cerebella to investigate the contribution of microglia to neuronal cell death induced by ...

Rotenone is a pesticide and piscicide, which causes behavioral and biochemical changes in rats that closely resemble PD symptoms in humans. Rotenone is a naturally occurring ret inoid plant ext ract derived from the roots of certain tropical and subtropical legume p lants and interferes with energy p roduction in the cell. Rotenone is highly lipophilic, so it can easily cross the blood brain ba...

Rotenone is a pesticide derived from the roots of plants from the Leguminosae family. Poisoning following deliberate ingestion of these plant roots has commonly been reported in Papua New Guinea. However, poisoning with commercially available rotenone in humans has been reported only once previously following accidental ingestion in a 3.5-year-old child. Therefore, the optimal management of rot...

BACKGROUND: Recent studies suggest that rotenone alters cell signal transduction pathways in a manner similar to glucocorticoids. Histological and biochemical markers of glucocorticoid effects in vivo, evaluated in our laboratories, provide further evidence for similarities in the activity of glucocorticoids and rotenone. The purpose of this study was to investigate the mechanism by which roten...

Various species of Absidia, Aspergillus, Cunninghamella, Trichothecium, Penicillium, and Phanerochaete were found to transform rotenone to one or more metabolites. Two biotransformation products were isolated from a preparative-scale incubation of rotenone with Cunninghamella blakesleeana and identified as 1',2'-dihydro-1',2'-dihydroxyrotenone and 3'-hydroxyrotenone (amorphigenin). The catalyti...

Much valuable information about the development of Parkinson’s disease (PD) has been obtained from studies on laboratory animals. Objectives. To compare neurotoxic and neuroinflammatory parkinsonism syndrome in Material methods. The number rats group model (lipopolysaccharide) was 6, (rotenone) - 20. control consisted 5 study approved by independent Ethics Committee. dynamics genesis assessed m...

Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both in vitro and in vivo. Studies have shown that the neurotoxicity of rotenone may be related to its ability to generate reactive oxygen species (ROS), leading to neuronal apoptosis. The current study was carried out to investigate the neuroprotective effects of hesperidi...

The present study was carried out to investigate the neuroprotective effects of isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model. SH-SY5Y human neuroblastoma cells were divided into four experimental groups (control, rotenone (100 nM), ILF (10 microM) + rotenone (100 nanoM)...

Systemic rotenone models of Parkinson's disease (PD) are highly reproducible and may provide evidence on the pathogenesis of PD. In the present study, male Sprague-Dawley rats (1-year-old) were subcutaneously administered with rotenone (1.5 mg/kg/day) for six days and observed for the following three weeks. Compared with the control rats, a significant decrease was observed in the body weight a...