نتایج جستجو برای: rare
تعداد نتایج: 240739 فیلتر نتایج به سال:
In the marine environment the planing of the sustainable development of economic activities requires long term information about the prevailing environmental conditions. Detailed knowledge on local wave conditions is an essential prerequisite for designing marine and coastal protection structures. To estimate the risk which emerges from local wave conditions knowledge on both, the wave climatol...
Despite the predominance of aquatic environments on the planet Earth, microbial abundance and diversity within soil environments exceed that of the aquatic realm. Most of what we know of viral ecology within natural systems has come through investigations of aquatic environments. However, the 'aquatic-bias' in viral ecology is beginning to change as the cultivation-independent approaches, which...
Background In general, large-scale clinical trials are needed to make definitive conclusions regarding changes in treatment practice. This is because treatment effects are often modest and large numbers of patients are needed to detect such differences with sufficient power for robust conclusions. Such trials are difficult and often impossible in rare diseases and their worth in this setting co...
Rick Lumpkin and Gustavo J. Goni (Physical Oceanography Division, Atlantic Oceanographic and Meteorological Laboratory, National Oceanic and Atmospheric Administration, Miami, Florida), Pedro N. DiNezio (Cooperative Institute for Marine and Atmospheric Studies, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Miami, Florida) and Nikolai A. Maximenko (International Pacif...
A 16 year old women with Tangier disease in palatine tonsils is reported. She has recurrent sore throat. In physical examination the palatine tonsils are hypertrophied and has very yellowish points. The facial skin is yellowish the skin of another areas of body is normal. After tonsillectomy the pathologist report Tangier disease in palatine tonsils.
The use of the case-cohort design for outbreak investigations has been limited. Here we discuss its strengths and limitations based on real and fictitious examples. The case-cohort is a case–control study where controls are sampled from the initial population at risk, and may thus include both cases and non-cases. An advantage of the design, compared to traditional case-control studies, is that...
BACKGROUND A relative inability to capture a sufficiently large patient population in any one geographic location has traditionally limited research into rare diseases. METHODS AND RESULTS Clinicians interested in the rare disease lymphangioleiomyomatosis (LAM) have worked with the LAM Treatment Alliance, the MIT Media Lab, and Clozure Associates to cooperate in the design of a state-of-the-a...
The authors describe the view of patients and patient organisations on gene therapy research and gene therapy regulations. In particular, the added value of partnership between scientists and patient organisations, and patient involvement in the gene therapy field, are addressed.
D. Trail, S. J. Mojzsis, T. M. Harrison, and H. F. Levison Department of Geological Sciences and Center of Astrobiology, University of Colorado, Boulder, Colorado 80309-0399 USA. Research School of Earth Sciences, Australian National University, Canberra ACT 0200 Australia. Department of Space Studies, Southwest Research Institute, Boulder, Colorado 80302 USA. ([email protected], mojzsi...
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