نتایج جستجو برای: rarb
تعداد نتایج: 280 فیلتر نتایج به سال:
Common sequence variants in cis-regulatory elements (CREs) are suspected etiological causes of complex disorders. We previously identified an intronic enhancer variant in the RET gene disrupting SOX10 binding and increasing Hirschsprung disease (HSCR) risk 4-fold. We now show that two other functionally independent CRE variants, one binding Gata2 and the other binding Rarb, also reduce Ret expr...
It remains unknown whether tobacco smoke induces DNA hypermethylation as an early event in carcinogenesis or as a late event, specific to overt cancer tissue. Using MethyLight assays, we analyzed 316 lung tissue samples from 151 cancer-free subjects (121 ever-smokers and 30 never-smokers) for hypermethylation of 19 genes previously observed to be hypermethylated in nonsmall cell lung cancers. O...
Impaired lung function, and consequent respiratory morbidity including asthma and chronic obstructive pulmonary disease, may have their origins in early life [1–3]. Genome-wide analysis studies (GWAS) have identified a number of single-nucleotide polymorphisms (SNPs) in those of European ancestry that affect adult lung function, as measured by forced expiratory volume in 1 s (FEV1) and FEV1/for...
DNA methylation and polycomb proteins are well-known mediators of epigenetic silencing in mammalian cells. Usually described as mutually exclusive, this statement is today controversial and recent in vitro studies suggest the co-existence of both repressor systems. We addressed this issue in the study of Retinoic Acid Receptor β (RARβ), a tumor suppressor gene frequently silenced in prostate ca...
Malformations in the eye can be caused by either an excess or deficiency of retinoids. An early target gene of the retinoid metabolite, retinoic acid (RA), is that encoding one of its own receptors, the retinoic acid receptor beta (RARbeta). To better understand the mechanisms underlying this autologous regulation, we characterized the chick RARbeta2 promoter. The region surrounding the transcr...
2249, and Ro44-4753, respectively. These synthetic retinoids were kindly provided by F. Hoffman-La Roche, Ltd (Basel, Switzerland). Our experiments also showed that the incubation of NB4 cells with the RARa selective agonist, Ro40-6055, induced cell differentiation into neutrophils and apoptosis. These effects were not exerted by Ro48-2249 and Ro44-4753. When NB4 cells were incubated with 0.01 ...
سابقه و هدف: با توجه به شیوع وروند رو به افزایش کانسر پروستات و تبعات شناخته شده آن و اهمیت اطلاع از عوامل بروز آن و وجود بعضی گزارشات مبنی بر نقش متیلاسیون پروموتر ژن های رتینوئیک اسید رسپتور بتا (RARB) و p16 با فاکتورهای پروگنوستیک کانسر پروستات، این تحقیق روی مبتلایان به کانسر پروستات با فاکتورهای پروگنوستیک بد (گروه مورد) و خوب (گروه شاهد2) و افراد سالم (گروه شاهد 1) در مراجعین به بیمارستان...
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