The radiobiological effects of high atomic number and energy (HZE particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. Space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. HZE particles pose a significant cancer risk to astronauts on prolonged space missions. With ...

Understanding the mechanism of tumor resistance is critical for cancer therapy. In this study, we investigated the effect of carcinoembryonic antigen (CEA) overexpression on UV-and 5-fluorouracil (5-FU)-induced apoptosis and autophagy in colorectal cancer cells. We used histone deacetylase (HDAC) inhibitor, NaB and DNA demethylating agent, 5- azacytidine (5-AZA) to induce CEA expression in HT29...

RATIONALE Computed tomography (CT) is being considered as a tool for routine monitoring of lung damage in people with cystic fibrosis. Concern has been raised, however, about the associated risk of radiation-induced cancer. OBJECTIVES To estimate the risk of radiation-induced cancer from lung CT for patients with cystic fibrosis, assuming annual monitoring starting at age 2 years. METHODS R...

background: radon is the second leading cause of lung cancer after smoking. in canada, the health authorities have no access to comprehensive profile of the communities built over uranium-rich micro-geological settings. the present indoor radon monitoring guideline is unable to provide an accurate identification of health hazards due to discounting several parameters of housing characteristics....

A number of methods for producing sub-picosecond electron bunches have been demonstrated in recent years. A train of these bunches is capable of generating THz radiation via multiple mechanisms like transition, Cherenkov and undulator radiation. We propose to use a bunch train like this to selectively excite a high order mode in a dielectric wakefield structure. This allows us to use wakefield ...

background: normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. the aim of t...