The correct measurement of the QT interval (using correction formulas, preferably Fridericia and Framingham) as well a interpretation causes clinical consequences prolongation is very important in practice. Drug-induced long syndrome (DILQTS) one most common LQTS. In diagnosis management DILQTS, it can be useful to follow three-step rule presented this article: detailed pharmacological anamnesi...

OBJECTIVES The purpose of this study was to evaluate the efficacy of various antiarrhythmic drugs at prolonging the QT interval into the normal range and preventing ventricular arrhythmias in patients with short QT syndrome. BACKGROUND Short QT syndrome is a recently described genetic disease characterized by short QT interval, high risk of sudden death, atrial fibrillation, and short refract...

he congenital long QT syndrome (LQTS) is characterized by abnormally prolonged ventricular repolarization, leading to QT prolongation on the ECG, with frequent development of the polymorphic ventricular tachycardia known as torsades de pointes (Tdp), syncope or sudden cardiac death.1,2 Most cases of congenital LQTS are caused by gene mutations in several ion channels and their interacting prote...

Prolongation of the QT interval on the surface 12-lead electrocardiogram is widely accepted as a biomarker for the potential of a drug to produce torsades de pointes and/or sudden death. Detection of drug-induced prolongation of the QT interval in animals and man is frequently confounded by extrinsic and intrinsic factors that limit the ability to detect a true drug effect. In particular drugs ...

Two cases of QT prolongation and torsades de pointes (TdP) are presented. The patients had been taking clarithromycin (400 mg/day) for respiratory disease. Although erythromycin is reportedly associated with TdP, this is the first report of clarithromycin associated with TdP in the absence of other drugs already known to produce QT prolongation.

BACKGROUND: Cirrhotic Cardiomyopathy is a relatively ill-characterized condition, which is often under-diagnosed due to absence of defined diagnostic criteria. ECG showing corrected QT Interval prolongation is the most suitable available option for diagnosis of this condition. OBJECTIVE: To determine the frequency of corrected QT interval prolongation in patients with liver cirrhosis. METHODOLO...

BACKGROUND Patients with a history of class Ia drug-induced torsade de pointes have been treated with chronic amiodarone without recurrence of torsade de pointes despite comparable prolongation of the QT interval. We hypothesized that in such patients, class Ia drugs cause nonhomogeneous prolongation of cardiac repolarization times, whereas amiodarone causes homogeneous prolongation of cardiac ...