OBJECTIVES Impaired social, role, and neurocognitive functioning are preillness characteristics of people who later develop psychosis. In people with schizophrenia, neurocognition and negative symptoms are associated with functional impairment. We examined the relative contributions of neurocognition and symptoms to social and role functioning over time in clinically high-risk (CHR) individuals...

INTRODUCTION Illnesses which develop in a complex way are best described in stages, and those stages will describe not only a particular point in the course of the disease but also the appropriate treatment for that stage. This approach has, over the years, proved to be very appropriate for planning the treatment of various cancers. It is suggested that in the same way, it can be very important...

AIMS The hypotensive reflex responsible for vasovagal syncope appears related to a reduction in sympathetic neural outflow. Several animal studies suggest that serotonin may play a role in the genesis of this reflex, through inhibition of sympathetic activity. However, the role of the serotonergic system is unknown in humans. The purpose of the study was to investigate the role of the serotoner...

Individual differences in temperament emerge in the first months of life. Some infants display a heightened sensitivity to novelty and uncertainty in the world around them, leading a subset to fearfully withdraw from the social environment. Extreme forms of this temperament, Behavioral inhibition (BI), are associated with increased risk for social anxiety disorder. Indeed, the link is so strong...

Two duplexes could become unwound locally in homologous regions which, it might be argued, could then rewind to form regions of hybrid DNA. The difficulty with this scheme is that, without breaks, each right-hand turn of the hybrid helix generated in this way must be compensated by a left-hand turn. No one who has attempted to build a stable left-handed double helix with molecular models has su...