The PRIMA-DBMS approach is explained by introducing PRIMA's architecture and query processing framework. The PRIMA-DBMS constitutes a testbed that is flexible enough to support evaluation and validation of quite a variation of different strategies for complex-object processing taking into account different parallelization levels and different hardware environments. Thus, PRIMA marks an importan...

Hepatocellular carcinoma (HCC) is highly lethal due to limited curative options. In high-incidence regions, such as parts of Africa and Southeastern Asia, >50% of cases carry an AGG to AGT mutation at codon 249 of the TP53 gene, considered as a 'signature' of mutagenesis by aflatoxins. The protein product, p53ser249, may represent a therapeutic target for HCC. The small molecule p53 reactivatio...

BACKGROUND The high disease burden of Africa, the emergence of new diseases and efforts to address the 10/90 gap have led to an unprecedented increase in health research activities in Africa. Consequently, there is an increase in the volume and complexity of protocols that ethics review committees in Africa have to review. METHODS With a grant from the Bill and Melinda Gates Foundation, the A...

Indonesia as an archipelagic country certainly has a great opportunity to develop the potential of marine tourism sector. Maritime in become prima donna for foreign and tourists, especially Labuan Bajo. Task Island - Kelor Karangan Makasar is new destination that currently being visited by many tourists. The design electric ships based on renewable energy expected be able answer limited access ...

Alterations of the TP53 tumor suppressor gene occur in ~30% of primary glioblastoma (GBM) with a high frequency of missense mutations associated with the acquisition of oncogenic "gain-of-function" (GOF) mutant (mut)p53 activities. PRIMA-1MET/APR-246, emerged as a promising compound to rescue wild-type (wt)p53 function in different cancer types. Previous studies suggested the role of wtp53 in t...

Mutation of the p53 tumor suppressor gene is a common event in many types of tumors, including breast cancers. Mutant p53 (mtp53) protein is thought to promote tumor cell survival and resistance to chemotherapeutic drugs. Therefore, restoring p53 function by converting existing mtp53 to the wild-type p53 (wtp53) conformation is being pursued as one strategy to promote apoptosis of tumor cells. ...

he relationship between medicine and religion belongs to the classical topics of medical history, in the studies of the so called early civilizations, mainly Egypt and Babylonia, of Greek and Roman antiquity, of the occidental and oriental Middle Ages and of the European early modern period. Yet about a century ago, preformed by enlightenment ideas on linear progress of humankind and often expl...