The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentr...

Department of Chemistry, Center for Metals 207 Pleasant St. SE, Minneapolis, MN 5545 Department of Chemistry, Yale University, N E-mail: [email protected] † Electronic supplementary information details, synthesis and preparation of [B kinetic plots, and spectroscopic data (P data for [Bu4N][LCu OAr2] (CIF). CCDC data in CIF or other electronic format see ‡ These authors made equal contributi...

Dynamic kinetic asymmetric amination of branched allylic acetimidates has been applied to the synthesis of 2-alkyl-dihydrobenzoazepin-5-ones. These seven-membered-ring aza ketones are prepared in good yield with high enantiomeric excess by rhodium-catalyzed allylic substitution with 2-amino aryl aldehydes followed by intramolecular olefin hydroacylation of the resulting alkenals. This two-step ...

objective: the aim of this study was to evaluate the non-genomic action of thyroxin on sperm kinetic and its probable use to improve sperm recovery after applying an enrichment method like “swim-up” in comparison with the available one, pentoxifylline. materials and methods: this is an experimental study. a total of 50 patients were recruited, followed by infertility consultation. conventional ...

A novel migratory dynamic kinetic resolution based on the interplay between an enzyme acylation catalyst and a heterogeneous Brønsted acid as an isomerization/racemization catalyst gives rise to carbocyclic allylic esters with excellent stereoselectivity from readily available tertiary carbinols. An easy-to-use teabag setup combining resin-bound catalysts, a biphasic isooctane-water solvent sys...

The total synthesis of a methylated analogue of (+)-Salvianolic acid C has been achieved. Key aspects of the synthetic route include an economical Cu(I) acetylide coupling, unique carboxyl activation conditions via microwave irradiation and a novel lipase catalysed kinetic resolution of a racemic mixture of secondary alcohol Danshensu. The preparation of this methylated analogue will not only i...

The effect of jasmonic acid on PSII reactions was assessed by changes in kinetic characteristics of O2 evolution and thermoluminesce glow curves in barley leaves and isolated thylakoid membranes. In comparison to the control preparation, JA-treated samples showed reduced efficiency in the utilization of oxidizing equivalents generated at PSII reaction centres and retardation of S-state transiti...

■ CONTENTS Kinetic Capillary Electrophoresis 157 Applications 159 Aptamers 159 KCE for Quantitative Characterization of Aptamer-Target Binding 159 KCE-Based Aptamer Selection 160 Small Molecules 161 Cyclodextrins 162 Proteins 162 Others 164 Instrumentation and Methodology 164 Sample Preparation 164 Capillary Coatings 165 KCE-MS 165 Computational and Mathematical Approaches 166 Validation 167 Co...