The incidence of melanoma and nonmelanoma skin cancers is increasing worldwide. Ultraviolet light exposure is the most important risk factor for cutaneous melanoma and nonmelanoma skin cancers. Nonmelanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma. Constitutive skin color and genetic factors, as well as immunological factors, play a role in the development of skin ca...

Ultraviolet (UV) radiation stimulates the expression of matrix metalloproteinases (MMPs) and inflammatory cytokines. These signaling pathways participate in the degradation of the extracellular matrix and induce inflammatory responses that lead to photoaging. This study evaluated the antioxidant activity and the effect on MMPs and procollagen of putgyul extract in vitro. The anti-photoaging act...

Aging skin is an issue of concern to many patients. In this review aging and photoaging are defined, mechanisms which underlie these processes explored, and available treatment options discussed.

Evidence from a randomized clinical trial showed that, in spite of the many surgical procedures effective in ameliorating the clinical appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene. The application of retinoids might not only clinically and biochemically repair photoaged ...

Ultraviolet radiation exposure is the dominant environmental determinant of all major forms skin cancer, and main cause prematurely aged that referred to as photoaging. Collagen type I (COL I) expressed differently along with dermis between healthy pathological tissues. The aim this study was understand impact solar in assess COL I. hematoxylin eosin staining protocol performed tissue paraffin ...

OBJECTIVE Determination of histopathological changes in different types of skin aging. METHODS AND RESULTS The study included a group of 60 women with various types of skin aging. Three groups were distinguished, each group containing 20 individuals. Group I consisted of women with menopausal skin aging, Group II with photoaging, and Group III with chronological aging. Biopsy specimens were t...

In traditional Korean/Asian medicine, Salvia plebeia R.Br. (S. plebeia) leaves are used to treat inflammatory diseases, including dermatitis, cough, asthma and toothache. Recently, S. plebeia leaves have been applied in skin care, as they promote skin lightening and elasticity. Therefore, the present study investigated the anti-aging effects of S. plebeia leaf methanolic extract and its fractio...

Theabrownin is a heterogeneous polyphenolic compound, obtained from fermented dark teas, with many bioactive functions. However, the role of theabrownin in skin photoaging remains unclear. In this study, we investigated whether modulates ultraviolet B (UVB)-induced matrix metalloprotease-1 (MMP-1) expression HaCaT keratinocytes. exerted antioxidant properties, which resulted scavenging intracel...