نتایج جستجو برای: p53 cells
تعداد نتایج: 1407387 فیلتر نتایج به سال:
Background: The effect of conditioned medium on apoptosis and invasion of MCF-7 is still debated. Carnosic acid, a component of rosemary extract, is also reported to have anti-cancer property. Therefore, we studied the occurrence of apoptosis through AIF-dependent pathway in MCF-7 cells treated with conditioned medium and rosemary extract by evaluating the expression of AIF, P53, Bcl-2 and Bax ...
ABSTRACT Bladder cancer consists of about 5.2% of all cancers in men and 2.3% in women. About 90% of them have the origin of transitional cells(TCC). There are some predictive factors that knowledge of them is useful for management and follow-up of the patients. Expression of oncoprotein P53 is one of these factors. Considering influence of P53 expression on prognosis, we decided ...
Recognition of the molecular mechanisms of cAMP action against DNA damage-induced apoptosis can be useful to improve the efficacy of DNA damaging therapeutic agents. Considering the critical role of bcl-2-associated death promoter (BAD) and p53 proteins in DNA damage -induced apoptosis, the aim of this study was to assess the effect of cAMP-elevating agents on these proteins in doxorubicin-trea...
Abstract Background Silica exposure underlies the development of silicosis, one most serious occupational hazards worldwide. We aimed to explore interaction silica-induced epithelial–mesenchymal transition (EMT)-related transcripts with cellular metabolism regulated by p53. Methods knocked out p53 using CRISPR/Cas9 in human bronchial epithelial (HBE) cell line. The transcriptomic and metabolomi...
Objective(s): Regarding the presence of many active biological constituents in Avicennia marina, the present investigation was carried out to study cytotoxic activity of crude methanol leave extract and column chromatographic fractions of A. marina against MDA-MB 231 cell line (human breast cancer cell) and HEK (Human embryonic kidney cell) line . Materials and Methods: The an...
Abstract Glioblastoma is the most frequent and malignant brain tumor. Immune therapies have had limited effect, but not much known about frequency type of immune cells in infiltration zone periphery. In these areas, tumor migrate into parenchyma prevent total resection thereby leading to recurrence. This study aims quantify distribution glioblastomas. A cohort 67 glioblastomas was established c...
The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...
Background: Loss of function in tumor suppressor genes is commonly associated with the onset/progression cancer and development therapeutic resistance. The p53 mutations resulting loss are common across variety tumors control cell proliferation more than 50% cancers. P53 null present about 10% driven However, to date there no effective treatment for rescuing We have developed a new potent strat...
Background: Breast cancer is one of the most common cancers in women. Nearly 30% of breast cancers are hormone-dependent, and these hormones comprising estrogens influence progression of breast cancers. It is now widely recognized that p53 may be the most frequently mutated protein in breast cancer. High levels of p53 protein are a common feature of many human malignant cancers. Given that, T47...
Multiplex Ligation-Dependent Probe Amplification (MLPA) was used to study the integrity of chromosomes for two WIL2-derived lymphoblastoid cell lines (TK6 and WTK1) in presence absence ionizing radiation. WTK1 cells contain a p53 mutation, whereas TK6 line has native tumor-suppressor gene. Each isolated pre- post-irradiation (2 3 Gy) analyzed by MLPA. Using probes that target specific regions o...
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