BACKGROUND Porous biphasic calcium phosphate (BCP) ceramics exhibit good biocompatibility and bone conduction but are not inherently osteoinductive. To overcome this disadvantage, we coated conventional porous BCP ceramics with nano-hydroxyapatite (nHA). nHA was chosen as a coating material due to its high osteoinductive potential. METHODS We used a hydrothermal deposition method to coat conv...

Autologous bone graft has been used for a long time as the only material capable of osteogenesis, osteoinductive and osteoconductive in regeneration medicine. However, revolutionary discoveries have introduced a wide range of bone regeneration materials (BRMs) with improved characteristics, comparable to those of the gold standard (autograft). Thus, the determination of the product for optimal ...

IntrOductIOn Treatment of large osseous bone defects is challenging. Autologous bone grafting is still the “biologic gold standard” against which all other forms are judged. Autograft enhances union by providing osteoconductive, osteoinductive and osteoprogenitor material to the fracture, nonunion and osseous defects. Unfortunately finite amount of graft available from each individual and addit...