The effect of Pavlovian discrimination training with two stimuli upon subsequent learning of an operant discrimination involving those stimuli was studied. After preliminary lever press training, the lever was removed and thirsty rats received noncontingent pairings between S(1) (a tone or a clicker) and water reinforcements, whereas S(2) (a clicker or a tone) occurred always without reinforcem...

A basic goal in the neurosciences is to understand the cellular mechanisms underlying associative learning. The 2 major forms of associative learning are classical conditioning and operant conditioning. In recent years considerable progress has been made towards a cellular analysis of classical conditioning in a number of different preparations. In contrast, the cellular mechanisms underlying o...

Operant discrimination learning has been extensively utilized in the study on the perceptual ability of animals and their higher order brain functions. We tested in this study whether American lobster Homarus americanus, which was previously found to possess ability of operant learning with claw gripping, could be trained to discriminate light stimuli of different intensities. For the current p...

In this review, we focus on neuronal operant conditioning in which increments in neuronal activities are directly rewarded without behaviors. We discuss the potential of this approach to elucidate neuronal plasticity for enhancing specific brain functions and its interaction with the progress in neurorehabilitation and brain-machine interfaces. The key to-be-conditioned activities that this pap...

Rationale—The endogenous cannabinoid (CB) system mediates a number of behaviors associated with drug-seeking and drug self-administration. In this study the effects of CB1 receptor manipulations on operant ethanol (EtOH) responding during EtOH-seeking, EtOHrelapse as well as on-going EtOH self-administration were determined. Methods—Alcohol-preferring (P) rats were trained in 2-lever operant ch...

Operant extinction is learning to supress a previously rewarded behavior. It is known to be strongly associated with the specific context in which it was acquired, which limits the therapeutic use of operant extinction in behavioral treatments, e.g., of addiction. We examined whether sleep influences contextual memory of operant extinction over time, using two different recall tests (Recent and...

BACKGROUND Operant behavioural testing provides a highly sensitive and automated method of exploring the behavioural deficits seen in rodent models of neurodegenerative diseases, including Huntington's disease (HD). The delayed matching to position (DMTP) and delayed non-matching to position (DNMTP) tasks probe spatial learning and working memory and when applied serially they can be used to me...

AIMS To assess whether cognitive biases for drug-related cues are associated with subjective craving and behavioural indices of drug-seeking behaviour, as predicted by incentive models of addiction. METHODS Fifty social drinkers took part in a laboratory study in which their subjective craving and cognitive biases for alcohol cues were assessed, before they completed a progressive ratio opera...

effects not achievable neither with rTMS alone nor with operant learning alone. Methods: Experimental approach: Forty-six subjects were randomly assigned to three experimental groups. Experimental groups 1 & 2 received a psychophysical pretest of tactile discrimination abilities with the left ring finger, a training procedure to improve performance with this finger, and a posttest. In experimen...

The prisoner's dilemma (PD) is the leading metaphor for the evolution of cooperative behavior in populations of selfish agents. Although cooperation in the iterated prisoner's dilemma (IPD) has been studied for over twenty years, most of this research has been focused on strategies that involve nonlearned behavior. Another approach is to suppose that players' selection of the preferred reply mi...